Gene

prkar1b

ID

ZDB-GENE-060929-580

Name

protein kinase, cAMP-dependent, regulatory, type I, beta

Symbol

prkar1b Nomenclature History

Previous Names

zgc:153624

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cGMP-mediated signaling. Predicted to localize to cytosol. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkar1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Marbach-Schaaf neurodevelopmental syndrome	619680

Associated With prkar1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018488	Cyclic nucleotide-binding, conserved site
Domain	IPR000595	Cyclic nucleotide-binding domain
Domain	IPR003117	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Domain	IPR042818	RIbeta, dimerization/docking domain
Family	IPR012198	cAMP-dependent protein kinase regulatory subunit
Family	IPR050503	cAMP-dependent kinase regulatory chain
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily

Domain Details Per Protein

Protein	Length	cAMP-dependent kinase regulatory chain	cAMP-dependent protein kinase regulatory subunit	cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain	Cyclic nucleotide-binding, conserved site	Cyclic nucleotide-binding domain	Cyclic nucleotide-binding domain superfamily	RIbeta, dimerization/docking domain	RmlC-like jelly roll fold
UniProtKB:Q08C49 InterPro	380

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prkar1b-201 (1) Ensembl	Ensembl	1,366 nt	Select Tool ZFIN BLAST
mRNA	prkar1b-202 (1) Ensembl	Ensembl	1,428 nt	Select Tool
mRNA	prkar1b-203 (1) Ensembl	Ensembl	1,182 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations