ZFIN ID: ZDB-GENE-060927-1
Gene Name: proprotein convertase subtilisin/kexin type 9
Gene Symbol: pcsk9
Sequence Ontology ID : SO:0000704

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Previous Name: NARC-1 (1)

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  brain, eye, gill, gonad (all 11) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23639 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-pcsk9 (1)
    PHENOTYPE
    Data: Fig. 6 from Poirier et al., 2006
    Observed in: hindbrain, midbrain hindbrain boundary, neurogenesis, optic tectum (all 5) expand
    DISEASE ASSOCIATED WITH pcsk9 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    {Low density lipoprotein cholesterol level QTL 1} 603776
    Hypercholesterolemia, familial, 3 603776
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system development (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000209 (1)
  • InterPro:IPR009020 (1)
  • InterPro:IPR010259 (1)
  • InterPro:IPR015500 (1)
  • InterPro:IPR022398 (1)
  • InterPro:IPR034193 (1)
  • PROSITE:PS00137 (1)
  • Pfam:PF00082 (1)
  • Pfam:PF05922 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-pcsk9 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pcsk9 No data available
    MARKER RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_003200677 (1) 2523bp
    Genomic GenBank:LO018182 (1)
    Polypeptide UniProtKB:E7F2J6 (1) 667aa
    Sequence Clusters UniGene:141795 (1)
    Sequence Information (all 6)
    OTHER pcsk9 GENE PAGES
  • Gene:100150316 (1)
  • Ensembl(GRCz10):ENSDARG00000074185 (1)
  • ORTHOLOGY for pcsk9 (Chr: 20)
    CITATIONS (13)