Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-060927-1
Gene Name: proprotein convertase subtilisin/kexin type 9
Gene Symbol: pcsk9
Previous Name: NARC-1 (1)
Location: Chr: 20   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  brain, eye, gill, gonad (all 11) expand
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa23639
Knockdown reagents: MO1-pcsk9 (1)
PHENOTYPE
Data: Fig. 6 from Poirier et al., 2006
Observed in: hindbrain, midbrain hindbrain boundary, neurogenesis, optic tectum (all 5) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Hypercholesterolemia, familial, 3 603776
{Low density lipoprotein cholesterol level QTL 1} 603776
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system development (more)
Molecular Function hydrolase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000209 (1)
  • InterPro:IPR009020 (1)
  • InterPro:IPR010259 (1)
  • InterPro:IPR015500 (1)
  • InterPro:IPR022398 (1)
  • PROSITE:PS00137 (1)
  • Pfam:PF00082 (1)
  • Pfam:PF05922 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-pcsk9 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcsk9 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_003200677 (1) 3104 bp
    Genomic GenBank:CABZ01065961 (1) 31925 bp
    Select Tool
    Polypeptide UniProtKB:E7F2J6 (1) 667 aa
    Sequence Clusters UniGene:141795 (1)
    Sequence Information (all 6)
    OTHER pcsk9 GENE PAGES
  • Gene:100150316 (1)
  • Ensembl(Zv9):ENSDARG00000074185 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish pcsk9 20  
    Human PCSK9 1 (1p32.3)
  • OMIM:607786
  • Gene:255738
  • Mouse Pcsk9 4 ( 49.67 cM)
  • MGI:2140260
  • Gene:100102
  • Orthology Details
    CITATIONS (11)