ZFIN ID: ZDB-GENE-060906-2
Gene Name: sodium channel, voltage gated, type VIII, alpha subunit b
Gene Symbol: scn8ab
Sequence Ontology ID : SO:0000704

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Previous Name: zscn1 (1)

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have voltage-gated sodium channel activity; predicted to be involved in membrane depolarization during action potential, neuronal action potential, and sodium ion transmembrane  ...
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH scn8ab HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 13 Epileptic encephalopathy, early infantile, 13 614558
Cognitive impairment with or without cerebellar ataxia 614306
Cognitive impairment with or without cerebellar ataxia 614306
Seizures, benign familial infantile, 5 617080
Seizures, benign familial infantile, 5 617080
?Myoclonus, familial, 2 618364
?Myoclonus, familial, 2 618364
DISEASE ASSOCIATED WITH scn8ab VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ion transport (more)
Cellular Component integral component of membrane (more)
Molecular Function ion channel activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001696 (1)
  • InterPro:IPR005821 (1)
  • InterPro:IPR008054 (1)
  • InterPro:IPR010526 (1)
  • InterPro:IPR024583 (1)
  • InterPro:IPR027359 (1)
  • Pfam:PF00520 (1)
  • Pfam:PF06512 (1)
  • Pfam:PF11933 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA scn8ab-202 (1) 6036
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM scn8ab No data available
    MARKER RELATIONSHIPS
    scn8abContained in: [BAC] CH211-173N18 (1) (order this), DKEY-195M11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045183 (1) 5877bp
    Genomic GenBank:CR753817 (1) 236737bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1RE76 (1) 1958aa
    Sequence Clusters UniGene:87506 (1)
    Sequence Information (all 30)
    OTHER scn8ab GENE PAGES
  • Alliance (1)
  • Gene:793996 (1)
  • VEGA:OTTDARG00000019885 (1)
  • ORTHOLOGY for scn8ab (Chr: 6)
    CITATIONS (21)