ZFIN ID: ZDB-GENE-060906-2
Gene Name: sodium channel, voltage gated, type VIII, alpha subunit b
Gene Symbol: scn8ab    Nomenclature History

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Previous Name: zscn1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have voltage-gated sodium channel activity. Predicted to be involved in membrane depolarization during action potential; neuronal action potential; and sodium ion transmembrane transport. Predicted to localize to axon and voltage-gated sodium channel complex. Is expressed in heart and nervous system. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and early infantile epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8).
Genome Resources: Alliance (1),  Gene:793996 (1),  Ensembl(GRCz11):ENSDARG00000018032 (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH scn8ab HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 13 Alliance Epileptic encephalopathy, early infantile, 13 614558
Cognitive impairment with or without cerebellar ataxia 614306
Seizures, benign familial infantile, 5 617080
?Myoclonus, familial, 2 618364
DISEASE ASSOCIATED WITH scn8ab VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ion transport (more)
Cellular Component integral component of membrane (more)
Molecular Function cation channel activity (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA scn8ab-202 (1)    Ensembl 6036
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM scn8ab No data available
MARKER RELATIONSHIPS
scn8ab Contained in: [BAC] CH211-173N18 (1), DKEY-195M11 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001045183 (1) 5877 nt
Genomic GenBank:CR753817 (1) 236737 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1RE76 (1) 1958 aa
Sequence Information (all 29)
ORTHOLOGY for scn8ab ( Chr: 6 )
CITATIONS (23)