ZFIN ID: ZDB-GENE-060825-69
Gene Name: LLGL scribble cell polarity complex component 1
Gene Symbol: llgl1    Nomenclature History

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Previous Name: zgc:153337

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have GTPase activator activity; Rab GTPase binding activity; and myosin II binding activity. Involved in cell projection assembly; regulation of Notch signaling pathway; and sensory system development. Localizes to basolateral plasma membrane. Is expressed in central nervous system; eye; head; and retina. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1).
Genome Resources: Alliance (1),  Gene:751760 (1),  Ensembl(GRCz11):ENSDARG00000009693 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11111 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31349 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-llgl1 N/A 4
    MO2-llgl1 N/A 3
    DISEASE ASSOCIATED WITH llgl1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH llgl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell projection assembly (more)
    Cellular Component basolateral plasma membrane (more)
    Molecular Function GTPase activator activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA llgl1-202 (1)    Ensembl 1059
    llgl1-203 (1)    Ensembl 1372
    llgl1-204 (1)    Ensembl 5400
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-llgl1 polyclonal Rabbit WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM llgl1 No data available
    MARKER RELATIONSHIPS
    llgl1 Contained in: [BAC] CH211-209H5 (1), DKEY-19E10 (1) (order this)
    llgl1 Encodes: [cDNA] MGC:153337 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045469 (1) 1111 nt
    Genomic GenBank:BX649547 (1) 237569 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E7FD67 (1) 1040 aa
    Sequence Information (all 23)
    ORTHOLOGY for llgl1 ( Chr: 3 )
    CITATIONS (20)