Gene
gabrr2a
- ID
- ZDB-GENE-060825-164
- Name
- gamma-aminobutyric acid type A receptor subunit rho2a
- Symbol
- gabrr2a Nomenclature History
- Previous Names
-
- zgc:153417
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Is predicted to contribute to GABA-A receptor activity and chloride channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to localize to several cellular components, including GABA-A receptor complex; integral component of plasma membrane; and neuron projection. Is expressed in nervous system. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cocco et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Family | IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
| Family | IPR008057 | Gamma-aminobutyric-acid A receptor, Rho |
| Family | IPR008059 | Gamma-aminobutyric-acid A receptor, Rho2 |
| Homologous_superfamily | IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
| Homologous_superfamily | IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | Gamma-aminobutyric-acid A receptor, Rho | Gamma-aminobutyric-acid A receptor, Rho2 | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QX34
|
475 | |||||||||
|
UniProtKB:Q0P445
|
371 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
gabrr2a-201
(1)
|
1623 nt | |
| mRNA |
gabrr2a-202
(1)
|
1559 nt |
Interactions and Pathways
No data available
Plasmids
No data available