Gene

pde5ab

ID
ZDB-GENE-060824-4
Name
phosphodiesterase 5A, cGMP-specific, b
Symbol
pde5ab Nomenclature History
Previous Names
  • pde5a
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Li et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pde5ab Human Ortholog
No data available
Associated With pde5ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain IPR003018 GAF domain
Domain IPR003607 HD/PDEase domain
Family IPR023088 3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily IPR029016 GAF-like domain superfamily
Homologous_superfamily IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Domain Details Per Protein
Protein Length 3'5'-cyclic nucleotide phosphodiesterase 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily 3'5'-cyclic nucleotide phosphodiesterase, conserved site GAF domain GAF-like domain superfamily HD/PDEase domain
UniProtKB:I6NQF5 318
UniProtKB:B0S7D6 867
UniProtKB:F1QZ12 870
UniProtKB:Q5U3S3 538
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-pde5a polyclonal IgG Rabbit
  • IHC
  • WB
GeneTex
2
Ab1-pde5a polyclonal Rabbit
  • IHC
  • WB
Aviva Systems Biology
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations