ZFIN ID: ZDB-GENE-060818-29
Gene Name: major facilitator superfamily domain containing 8
Gene Symbol: mfsd8    Nomenclature History

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Previous Names: im:7139494, zgc:136865 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to be involved in transmembrane transport. Predicted to localize to integral component of membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8).
Genome Resources: Alliance (1),  Gene:564342 (1),  Ensembl(GRCz11):ENSDARG00000103235 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7139494]
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018118Tg Transgenic Insertion Unknown Unknown DNA
sa2646 Point Mutation Unknown Splice Site ENU
sa27950 Point Mutation Unknown Premature Stop ENU
sa42028 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45459 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mfsd8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neuronal ceroid lipofuscinosis 7 Alliance Ceroid lipofuscinosis, neuronal, 7 610951
    Macular dystrophy with central cone involvement 616170
    DISEASE ASSOCIATED WITH mfsd8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane transporter activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mfsd8-201 (1)    Ensembl 2907
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mfsd8 No data available
    MARKER RELATIONSHIPS
    mfsd8 Contained in: [BAC] CH211-222B21 (1), DKEY-219E21 (1) (order this)
    mfsd8 Encodes: [EST] IMAGE:7139494 (1)
    [cDNA] MGC:136865 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045048 (1) 2890 nt
    Genomic GenBank:CR848021 (1) 162146 nt
    Select Tool
    Polypeptide UniProtKB:Q0VA82 (1) 504 aa
    Sequence Information (all 14)
    ORTHOLOGY for mfsd8 ( Chr: 12 )
    CITATIONS (26)