ZFIN ID: ZDB-GENE-060815-3
Gene Name: catenin (cadherin-associated protein), alpha 2
Gene Symbol: ctnna2    Nomenclature History

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Previous Names: im:5410539, si:rp71-1h10.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; cadherin binding activity; and structural molecule activity. Predicted to be involved in several processes, including brain morphogenesis; neuron projection morphogenesis; and regulation of synapse structural plasticity. Predicted to localize to adherens junction; axon; and cytoplasm. Is expressed in female organism. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CTNNA2 (catenin alpha 2).
Genome Resources: Alliance (1),  Gene:567500 (1),  Ensembl(GRCz11):ENSDARG00000024785 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu764]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:5410539]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028152Tg Transgenic Insertion Unknown Unknown DNA
la028153Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2006 Point Mutation Unknown Premature Stop ENU
    sa16103 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32731 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32732 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ctnna2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cortical dysplasia, complex, with other brain malformations 9 618174
    DISEASE ASSOCIATED WITH ctnna2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component adherens junction (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctnna2-201 (1)    Ensembl 3382
    ctnna2-204 (1)    Ensembl 1560
    ctnna2-205 (1)    Ensembl 899
    ncRNA ctnna2-004 (1)    Ensembl 554
    ctnna2-005 (1) 822
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctnna2 No data available
    MARKER RELATIONSHIPS
    ctnna2 Contained in: [BAC] CH211-10C20 (1), CH211-71K14 (1), CH211-87B14 (1), CH211-243L5 (1), DKEY-230I19 (1) (order this), DKEYP-13B9 (1), DKEYP-50E3 (1), RP71-1H10 (1)
    [Fosmid] CH1073-15I3 (1)
    ctnna2 Encodes: [EST] eu764 (1), IMAGE:5410539 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001159372 (1) 2598 nt
    Genomic GenBank:AL929516 (1) 165892 nt
    Select Tool
    Polypeptide UniProtKB:X1WG13 (1) 521 aa
    Sequence Information (all 45)
    ORTHOLOGY for ctnna2 ( Chr: 1 )
    CITATIONS (31)