Gene

acaca

ID
ZDB-GENE-060526-74
Name
acetyl-CoA carboxylase alpha
Symbol
acaca Nomenclature History
Previous Names
  • acc (1)
  • fj43d01
  • im:7138837 (1)
  • si:ch211-199d18.1
  • wu:fj43d01 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; acetyl-CoA carboxylase activity; and metal ion binding activity. Involved in response to (R)-carnitine. Is expressed in liver and male organism. Orthologous to human ACACA (acetyl-CoA carboxylase alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acaca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Acetyl-CoA carboxylase deficiency 613933
Associated With acaca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR001882 Biotin-binding site
Domain IPR000089 Biotin/lipoyl attachment
Domain IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Domain IPR005481 Biotin carboxylase-like, N-terminal domain
Domain IPR005482 Biotin carboxylase, C-terminal
Domain IPR011761 ATP-grasp fold
Domain IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
Domain IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
Domain IPR011764 Biotin carboxylation domain
Domain IPR013537 Acetyl-CoA carboxylase, central domain
Homologous_superfamily IPR011053 Single hybrid motif
Homologous_superfamily IPR011054 Rudiment single hybrid motif
Homologous_superfamily IPR013815 ATP-grasp fold, subdomain 1
Homologous_superfamily IPR016185 Pre-ATP-grasp domain superfamily
Homologous_superfamily IPR029045 ClpP/crotonase-like domain superfamily
Domain Details Per Protein
Protein Length Acetyl-CoA carboxylase, central domain Acetyl-coenzyme A carboxyltransferase, C-terminal Acetyl-coenzyme A carboxyltransferase, N-terminal ATP-grasp fold ATP-grasp fold, subdomain 1 Biotin-binding site Biotin carboxylase, C-terminal Biotin carboxylase-like, N-terminal domain Biotin carboxylation domain Biotin/lipoyl attachment Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain ClpP/crotonase-like domain superfamily Pre-ATP-grasp domain superfamily Rudiment single hybrid motif Single hybrid motif
UniProtKB:A0A8M6YZ52 2349
UniProtKB:A0A8M9PK80 2425
UniProtKB:A0A8M9QE20 2326
UniProtKB:A0A2R8QJA0 2375
UniProtKB:A0A8M9Q3F9 2348
UniProtKB:A0A8M6Z6X1 2368
UniProtKB:A0A8M6Z6C9 2341
UniProtKB:A0A8M9Q8Q1 2391
UniProtKB:F6P055 2383
UniProtKB:A0A8M9PK85 2383
UniProtKB:A0A8M9Q3F2 2418
UniProtKB:A0A8M1NZ82 2390
UniProtKB:A0A8M9QE14 2410
UniProtKB:A0A8M6YY91 2356
UniProtKB:A0A8M9PXQ3 2376
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations