Gene

acaca

ID
ZDB-GENE-060526-74
Name
acetyl-CoA carboxylase alpha
Symbol
acaca Nomenclature History
Previous Names
  • acc (1)
  • fj43d01
  • im:7138837 (1)
  • si:ch211-199d18.1
  • wu:fj43d01 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; acetyl-CoA carboxylase activity; and metal ion binding activity. Involved in response to (R)-carnitine. Is expressed in liver and male organism. Orthologous to human ACACA (acetyl-CoA carboxylase alpha).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acaca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Acetyl-CoA carboxylase deficiency 613933
Associated With acaca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR001882 Biotin-binding site
Domain IPR000089 Biotin/lipoyl attachment
Domain IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Domain IPR005481 Biotin carboxylase-like, N-terminal domain
Domain IPR005482 Biotin carboxylase, C-terminal
Domain IPR011761 ATP-grasp fold
Domain IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
Domain IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
Domain IPR011764 Biotin carboxylation domain
Domain IPR013537 Acetyl-CoA carboxylase, central domain
Domain IPR034733 Acetyl-CoA carboxylase
Homologous_superfamily IPR011053 Single hybrid motif
Homologous_superfamily IPR011054 Rudiment single hybrid motif
Homologous_superfamily IPR013815 ATP-grasp fold, subdomain 1
Homologous_superfamily IPR016185 Pre-ATP-grasp domain superfamily
Homologous_superfamily IPR029045 ClpP/crotonase-like domain superfamily
Domain Details Per Protein
Protein Length Acetyl-CoA carboxylase Acetyl-CoA carboxylase, central domain Acetyl-coenzyme A carboxyltransferase, C-terminal Acetyl-coenzyme A carboxyltransferase, N-terminal ATP-grasp fold ATP-grasp fold, subdomain 1 Biotin-binding site Biotin carboxylase, C-terminal Biotin carboxylase-like, N-terminal domain Biotin carboxylation domain Biotin/lipoyl attachment Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain ClpP/crotonase-like domain superfamily Pre-ATP-grasp domain superfamily Rudiment single hybrid motif Single hybrid motif
UniProtKB:A8WG34 253
UniProtKB:A0A2R8RIG4 2338
UniProtKB:A0A2R8QJA0 2375
UniProtKB:F1QH12 2390
UniProtKB:F6P055 2383
UniProtKB:A0A2R8QPK9 2376
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations