Gene

bmp10

ID

ZDB-GENE-060526-211

Name

bone morphogenetic protein 10

Symbol

bmp10 Nomenclature History

Previous Names

bmp10b (1)
si:dkey-13n15.5

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Is predicted to enable cytokine activity. Involved in SMAD protein signal transduction and positive regulation of pathway-restricted SMAD protein phosphorylation. Acts upstream of or within artery development. Predicted to be located in extracellular region. Is expressed in liver and pericardial region. Used to study hereditary hemorrhagic telangiectasia. Orthologous to human BMP10 (bone morphogenetic protein 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bmp10 Human Ortholog

No data available

Associated With bmp10 Via Experimental Models

Human Disease	Fish	Conditions	Citations
hereditary hemorrhagic telangiectasia	bmp10^pt527/pt527; pt505Tg; twu34Tg	control	Capasso et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine