ZFIN ID: ZDB-GENE-060518-5
Gene Name: ubiquitin specific peptidase 40
Gene Symbol: usp40    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Involved in pronephric glomerulus development. Predicted to localize to the cytosol. Is expressed in pronephric glomerulus. Orthologous to human USP40 (ubiquitin specific peptidase 40).
Genome Resources: Alliance (1),  Gene:402834 (1),  Ensembl(GRCz11):ENSDARG00000071197 (2)
GENE EXPRESSION
All Expression Data: Fig. 8 from Takagi et al., 2017
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20637 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20638 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20639 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26680 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-usp40 N/A 1
    MO2-usp40 N/A 1
    DISEASE ASSOCIATED WITH usp40 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH usp40 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephric glomerulus development (more)
    Molecular Function thiol-dependent ubiquitinyl hydrolase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018200 Ubiquitin specific protease, conserved site
    Domain IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    Domain IPR028889 Ubiquitin specific protease domain
    Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA usp40-201 (1)    Ensembl 4651
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-usp40 polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM usp40 No data available
    MARKER RELATIONSHIPS
    usp40 Contained in: [BAC] CH73-267F5
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001921318 (1)
    Genomic GenBank:CU571254 (1) 56594 nt
    Select Tool
    Polypeptide UniProtKB:F1Q7D2 (1) 1263 aa
    Sequence Information (all 8)
    ORTHOLOGY for usp40 ( Chr: 6 )
    CITATIONS (18)