Gene
usp22
- ID
- ZDB-GENE-060512-211
- Name
- ubiquitin specific peptidase 22
- Symbol
- usp22 Nomenclature History
- Previous Names
-
- zgc:136342
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have thiol-dependent ubiquitinyl hydrolase activity and zinc ion binding activity. Predicted to be involved in chromatin organization; protein deubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to several human genes including USP22 (ubiquitin specific peptidase 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tse et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR001607 | Zinc finger, UBP-type |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, UBP-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QEE8
|
507 | ||||||
|
UniProtKB:A0A8M9QMM5
|
506 | ||||||
|
UniProtKB:A6H8I0
|
506 |
Interactions and Pathways
No data available
Plasmids
No data available