Gene
kdm4b
- ID
- ZDB-GENE-060503-664
- Name
- lysine (K)-specific demethylase 4B
- Symbol
- kdm4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have histone demethylase activity (H3-K9 specific). Predicted to be involved in chromatin remodeling. Predicted to localize to histone methyltransferase complex. Human ortholog(s) of this gene implicated in several diseases, including autistic disorder; gastrointestinal system cancer (multiple); head and neck cancer; malignant peripheral nerve sheath tumor; and withdrawal disorder. Is expressed in caudal hematopoietic tissue. Orthologous to several human genes including KDM4B (lysine demethylase 4B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yu et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder, autosomal dominant 65 | 619320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR002999 | Tudor domain |
| Domain | IPR003347 | JmjC domain |
| Domain | IPR003349 | JmjN domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR034732 | Extended PHD (ePHD) domain |
| Domain | IPR040477 | Lysine-specific demethylase 4-like, Tudor domain |
| Domain | IPR047483 | Lysine-specific demethylase 4B, first Tudor domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Length | Extended PHD (ePHD) domain | JmjC domain | JmjN domain | Lysine-specific demethylase 4B, first Tudor domain | Lysine-specific demethylase 4-like, Tudor domain | Tudor domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LUQ0
|
1134 | ||||||||||
|
UniProtKB:A0A8M9P494
|
1132 |
Interactions and Pathways
No data available
Plasmids
No data available