ZFIN ID: ZDB-GENE-060503-664
Gene Name: lysine (K)-specific demethylase 4B
Gene Symbol: kdm4b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: jmjd2b (1), si:ch211-124a3.4 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have histone demethylase activity (H3-K9 specific). Predicted to be involved in chromatin remodeling. Predicted to localize to histone methyltransferase complex. Is expressed in caudal hematopoietic tissue. Human ortholog(s) of this gene implicated in several diseases, including autistic disorder; gastrointestinal system cancer (multiple); head and neck cancer; malignant peripheral nerve sheath tumor; and withdrawal disorder. Orthologous to several human genes including KDM4B (lysine demethylase 4B).
Genome Resources: Alliance (1),  Gene:556504 (1),  Ensembl(GRCz11):ENSDARG00000099675 (1)
GENE EXPRESSION
All Expression Data: Fig. S1 from Yu et al., 2018
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022356Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10758 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15777 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17996 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44979 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kdm4b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kdm4b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH kdm4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chromatin remodeling (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdm4b-201 (1)    Ensembl 5293
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm4b No data available
    MARKER RELATIONSHIPS
    kdm4b Contained in: [BAC] CH211-124A3 (1)
    [Fosmid] CH1073-159L14 (1)
    kdm4b Encodes: [cDNA] MGC:198425 (1), MGC:198427 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001082805 (1) 5293 nt
    Genomic GenBank:BX927276 (1) 166844 nt
    Select Tool
    Polypeptide UniProtKB:Q1LUQ0 (1) 1134 aa
    Sequence Information (all 19)
    ORTHOLOGY for kdm4b ( Chr: 22 )
    CITATIONS (26)