Gene

gabbr2

ID
ZDB-GENE-060503-620
Name
gamma-aminobutyric acid (GABA) B receptor, 2
Symbol
gabbr2 Nomenclature History
Previous Names
  • si:dkey-190l1.2
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to localize to G protein-coupled receptor heterodimeric complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 59 and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gabbr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 59 Alliance Developmental and epileptic encephalopathy 59 617904
Neurodevelopmental disorder with poor language and loss of hand skills 617903
{Nicotine dependence, protection against} 188890
{Nicotine dependence, susceptibility to} 188890
Associated With gabbr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017979 GPCR, family 3, conserved site
Domain IPR001828 Receptor, ligand binding region
Domain IPR017978 GPCR family 3, C-terminal
Domain IPR041689 Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain
Family IPR000337 GPCR, family 3
Family IPR002455 GPCR family 3, GABA-B receptor
Family IPR002457 GPCR family 3, gamma-aminobutyric acid receptor, type B2
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain GPCR, family 3 GPCR, family 3, conserved site GPCR family 3, C-terminal GPCR family 3, GABA-B receptor GPCR family 3, gamma-aminobutyric acid receptor, type B2 Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:Q1LUN9 935
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations