ZFIN ID: ZDB-GENE-060503-620
Gene Name: gamma-aminobutyric acid (GABA) B receptor, 2
Gene Symbol: gabbr2    Nomenclature History

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Previous Name: si:dkey-190l1.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to localize to G protein-coupled receptor heterodimeric complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 59 and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2).
Genome Resources: Alliance (1),  Gene:560267 (1),  Ensembl(GRCz11):ENSDARG00000061042 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39253 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43313 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gabbr2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 59 Alliance Epileptic encephalopathy, early infantile, 59 617904
    Neurodevelopmental disorder with poor language and loss of hand skills 617903
    {Nicotine dependence, protection against} 188890
    {Nicotine dependence, susceptibility to} 188890
    DISEASE ASSOCIATED WITH gabbr2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled GABA receptor activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gabbr2-201 (1)    Ensembl 2808
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gabbr2 No data available
    MARKER RELATIONSHIPS
    gabbr2 Contained in: [BAC] CH211-9N13 (1), CH211-10D14 (1), CH211-124E6 (1), CH211-226I21 (1), CH211-266K5 (1), DKEY-190L1 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001144043 (1)
    Genomic GenBank:BX649545 (1) 169802 nt
    Select Tool
    Polypeptide UniProtKB:Q1LUN9 (1) 935 aa
    Sequence Information (all 16)
    ORTHOLOGY for gabbr2 ( Chr: 19 )
    CITATIONS (22)