Gene

gabbr2

ID
ZDB-GENE-060503-620
Name
gamma-aminobutyric acid (GABA) B receptor, 2
Symbol
gabbr2 Nomenclature History
Previous Names
  • si:dkey-190l1.2
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to localize to G protein-coupled receptor heterodimeric complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 59 and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gabbr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 59 Alliance Developmental and epileptic encephalopathy 59 617904
Neurodevelopmental disorder with poor language and loss of hand skills 617903
{Nicotine dependence, protection against} 188890
{Nicotine dependence, susceptibility to} 188890
Associated With gabbr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017979 GPCR, family 3, conserved site
Domain IPR001828 Receptor, ligand binding region
Domain IPR017978 GPCR family 3, C-terminal
Domain IPR041689 Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain
Family IPR000337 GPCR, family 3
Family IPR002455 GPCR family 3, GABA-B receptor
Family IPR002457 GPCR family 3, gamma-aminobutyric acid receptor, type B2
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Domain Details Per Protein
Protein Length Gamma-aminobutyric acid type B receptor subunit 2, coiled-coil domain GPCR, family 3 GPCR, family 3, conserved site GPCR family 3, C-terminal GPCR family 3, GABA-B receptor GPCR family 3, gamma-aminobutyric acid receptor, type B2 Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:Q1LUN9 935
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations