Gene

slc5a5

ID
ZDB-GENE-060503-585
Name
solute carrier family 5 member 5
Symbol
slc5a5 Nomenclature History
Previous Names
  • NIS (1)
  • si:ch211-200a16.4
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits sodium:iodide symporter activity. Predicted to be involved in iodide transmembrane transport and sodium ion transport. Predicted to localize to integral component of membrane. Is expressed in thyroid follicle and thyroid primordium. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc5a5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thyroid dyshormonogenesis 1 Alliance Thyroid dyshormonogenesis 1 274400
Associated With slc5a5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001734 Sodium/solute symporter
Homologous_superfamily IPR038377 Sodium/glucose symporter superfamily
Domain Details Per Protein
Protein Length Sodium/glucose symporter superfamily Sodium/solute symporter
UniProtKB:A4IG60 601
UniProtKB:Q1LY42 566
UniProtKB:Q208V1 368
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations