Gene

vars2

ID
ZDB-GENE-060503-575
Name
valyl-tRNA synthetase 2, mitochondrial
Symbol
vars2 Nomenclature History
Previous Names
  • si:ch211-152p11.2
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 20 Alliance Combined oxidative phosphorylation deficiency 20 615917
Associated With vars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR002300 Aminoacyl-tRNA synthetase, class Ia
Domain IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain IPR033705 Valyl tRNA synthetase, anticodon-binding domain
Family IPR002303 Valine-tRNA ligase
Homologous_superfamily IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Aminoacyl-tRNA synthetase, class I, conserved site Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding Rossmann-like alpha/beta/alpha sandwich fold Valine-tRNA ligase Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain Valyl tRNA synthetase, anticodon-binding domain
UniProtKB:A3KQ02 861
UniProtKB:B3DIT4 1057
UniProtKB:F1QSW0 1057
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations