FIGURE
Fig. 1
- ID
- ZDB-FIG-220713-56
- Publication
- Kayvanpour et al., 2022 - VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation
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Fig. 1
Figure 1. Phenotype of VARS2-MO-injected embryos in comparison to control-MO-injected embryos with 73% knockdown efficiency: n = 100 control-MO- and n = 100 splice-MO-injected embryos. Scale bar: 0.5mm (A). Heart rate and ventricular fractional shortening in control-MO- and splice-MO-injected embryos at 48h, 72h, and 96h post-fertilization (n = 25 each) (B). Gel electrophoresis showing a fraction of wild-type cDNA consisting of exons 2, 3, and 4 (241 bp) in control-MO-injected embryos and both wild-type and spliced cDNAs in splice-MO-injected embryos, with spliced cDNA missing exon 3 (159bp) (C). Whole-mount RNA antisense in situ hybridization showing expressions of atrial- and ventricle-specific myosin heavy chains as well as notch1b (D). v: ventricle, a: atrium, hpf: hours post-fertilization. Scale bar: 100µm.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
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| Knockdown Reagent: | |
| Observed In: | |
| Stage: | Protruding-mouth |
Phenotype Detail
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Full text @ Int. J. Mol. Sci.