ZFIN ID: ZDB-GENE-060503-458
Gene Name: protein tyrosine phosphatase non-receptor type 22
Gene Symbol: ptpn22    Nomenclature History

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Previous Name: si:dkey-78k11.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); rheumatoid arthritis (multiple); and vasculitis (multiple). Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22).
Genome Resources: Alliance (1),  Gene:565606 (1),  Ensembl(GRCz11):ENSDARG00000104197 (1)
GENE EXPRESSION
All Expression Data: Fig. 4 from van Eekelen et al., 2010
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ptpn22 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
rheumatoid arthritis Alliance {Rheumatoid arthritis, susceptibility to} 180300
systemic lupus erythematosus Alliance {Systemic lupus erythematosus susceptibility to} 152700
type 1 diabetes mellitus Alliance {Diabetes, type 1, susceptibility to} 222100
DISEASE ASSOCIATED WITH ptpn22 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process dephosphorylation (more)
Cellular Component cytoplasm (more)
Molecular Function hydrolase activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000242 PTP type protein phosphatase
Domain IPR000387 Tyrosine specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ptpn22-202 (1)    Ensembl 585
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ptpn22 No data available
MARKER RELATIONSHIPS
ptpn22 Contained in: [BAC] DKEY-78K11 (1) (order this)
ptpn22 Encodes: [cDNA] MGC:162702 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001099420 (1) 3187 bp
Genomic GenBank:AL845287 (1) 174301 bp
Select Tool
Polypeptide UniProtKB:A0A0R4IER5 (1) 887 aa
Sequence Information (all 21)
ORTHOLOGY for ptpn22 ( Chr: 23 )
CITATIONS (20)