ZFIN ID: ZDB-GENE-060503-341
Gene Name: DOT1-like histone H3K79 methyltransferase
Gene Symbol: dot1l
Previous Name: si:dkey-211f22.1
Location: Chr: 22   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. 7 from Mahmoudi et al., 2010
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  hindbrain, intestine, midbrain
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: dot1lsa1413/sa1413(Tupfel long fin)
Knockdown reagents: MO1-dot1l (1), MO2-dot1l (1), MO3-dot1l (1)

Allele Type Mutagen Suppliers
sa1413 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17278 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa17639 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dot1l HUMAN ORTHOLOG No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR013110 (1)
  • InterPro:IPR017956 (1)
  • InterPro:IPR025789 (1)
  • InterPro:IPR029063 (1)
  • InterPro:IPR030445 (1)
  • PROSITE:PS51569 (1)
  • Pfam:PF08123 (1)
  • EC:2.1.1.43 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dot1l-001 (1) 3593
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dot1l No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dot1l Contained in: [BAC] DKEY-211F22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:BX005098 (1) 100658 bp
    Select Tool
    Polypeptide UniProtKB:F1Q4W7 (1) 1523 aa
    Sequence Information (all 3)
    OTHER dot1l GENE PAGES
  • VEGA:OTTDARG00000014160 (1)
  • Ensembl(Zv9):ENSDARG00000061992 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dot1l 22  
    Human DOT1L 19 (19p13.3)
  • OMIM:607375
  • Gene:84444
  • Mouse Dot1l 10 ( 39.72 cM)
  • MGI:2143886
  • Gene:208266
  • Orthology Details
    CITATIONS (15)