ZFIN ID: ZDB-GENE-060503-341
Gene Name: DOT1-like histone H3K79 methyltransferase
Gene Symbol: dot1l

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Previous Name: si:dkey-211f22.1

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  hindbrain, intestine, midbrain, whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1413 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17278 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17639 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37502 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39369 Point Mutation Unknown Splice Site ENU
    sa43825 Point Mutation Unknown Premature Stop ENU
    sa43826 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-dot1l (1), MO2-dot1l (1), MO3-dot1l (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dot1l HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function histone methyltransferase activity (H3-K79 specific) (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR025789 (1)
  • InterPro:IPR029063 (1)
  • InterPro:IPR030445 (1)
  • PROSITE:PS51569 (1)
  • Pfam:PF08123 (1)
  • EC:2.1.1.43 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dot1l-001 (1) 3593
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM dot1l No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dot1lContained in: [BAC] DKEY-211F22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:BX005098 (1) 100658bp
    Select Tool
    Polypeptide UniProtKB:F1Q4W7 (1) 1523aa
    Sequence Information (all 3)
    OTHER dot1l GENE PAGES
  • VEGA:OTTDARG00000014160 (1)
  • Ensembl(GRCz10):ENSDARG00000061992 (1)
  • ORTHOLOGY for dot1l (Chr: 22)
    Species Symbol Chromosome Accession # Evidence
    Human DOT1L 19
  • Gene:84444
  • OMIM:607375
  • HGNC:24948
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Dot1l 10
  • MGI:2143886
  • Gene:208266
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (16)