ZFIN ID: ZDB-GENE-060503-341
Gene Name: DOT1-like histone H3K79 methyltransferase
Gene Symbol: dot1l    Nomenclature History

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Previous Name: si:dkey-211f22.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have histone methyltransferase activity (H3-K79 specific). Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia. Is expressed in hindbrain; intestine; and midbrain. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000061992 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
DISEASE ASSOCIATED WITH dot1l HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH dot1l VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process canonical Wnt signaling pathway (more)
Cellular Component nucleus (more)
Molecular Function histone-lysine N-methyltransferase activity (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR025789 Histone-lysine N-methyltransferase DOT1 domain
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Family IPR030445 Histone H3-K79 methyltransferase
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dot1l-202 (1)    Ensembl 3593
Browsers: EnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dot1l No data available
MARKER RELATIONSHIPS
dot1l Contained in: [BAC] DKEY-211F22 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
Genomic GenBank:BX005098 (1) 100658 bp
Select Tool
Polypeptide UniProtKB:F1Q4W7 (1) 1454 aa
Sequence Information (all 5)
ORTHOLOGY for dot1l ( Chr: 22 )
CITATIONS (22)