ZFIN ID: ZDB-GENE-060429-1
Gene Name: polymerase (DNA directed), delta 1, catalytic subunit
Gene Symbol: pold1

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Previous Names: fla, flat head, im:7139126, zgc:152688

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(Including Attributions)
Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 14 figures from 2 publications
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2004 [IMAGE:7139126]
  6 figures (6 images) from Thisse et al., 2004 [IMAGE:7160082]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, ciliary marginal zone, digestive system, immature eye (all 12) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12879 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17444 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa18749 Point Mutation Unknown Splice Site ENU
    ta53c Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf21c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th5b Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tu255e Unknown Unknown Unknown ENU
    ty76 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 12 figures from 3 publications
    Observed in: brain, ceratobranchial 5 bone, ceratobranchial 5 tooth, ceratohyal cartilage (all 22) expand
    DISEASE ASSOCIATED WITH pold1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    colorectal cancer {Colorectal cancer, susceptibility to, 10} 612591
    Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 615381
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA replication (more)
    Cellular Component delta DNA polymerase complex (more)
    Molecular Function 3'-5' exonuclease activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006133 (1)
  • InterPro:IPR006134 (1)
  • InterPro:IPR006172 (1)
  • InterPro:IPR012337 (1)
  • InterPro:IPR017964 (1)
  • InterPro:IPR023211 (1)
  • InterPro:IPR025687 (1)
  • PROSITE:PS00116 (1)
  • Pfam:PF00136 (1)
  • Pfam:PF03104 (1)
  • Pfam:PF14260 (1)
  • EC:2.7.7.7 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pold1-002 (1) 3561
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pold1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pold1Contained in: [BAC] DKEY-29B22 (1) (order this), DKEY-30J10 (1) (order this)
    pold1Encodes: [EST] IMAGE:7139126 (1) (order this), IMAGE:7160082 (1) (order this)
    [cDNA] MGC:152688 (1), MGC:195302 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001039810 (1) 3561bp
    Genomic GenBank:CR847509 (1) 157983bp
    Select Tool
    Polypeptide UniProtKB:B3DKJ9 (1) 1105aa
    Sequence Clusters UniGene:49022 (1)
    Sequence Information (all 17)
    OTHER pold1 GENE PAGES
  • Gene:556456 (1)
  • VEGA:OTTDARG00000019271 (1)
  • Ensembl(GRCz10):ENSDARG00000027689 (1)
  • ORTHOLOGY for pold1 (Chr: 3)
    Species Symbol Chromosome Accession # Evidence
    Human POLD1 19
  • Gene:5424
  • OMIM:174761
  • HGNC:9175
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Pold1 7
  • MGI:97741
  • Gene:18971
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (30)