ZFIN ID: ZDB-GENE-060421-4643
Gene Name: BAF chromatin remodeling complex subunit BCL11A a
Gene Symbol: bcl11aa    Nomenclature History

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Previous Names: bcl11a.1 (1), bcl11a, fi09f10, wu:fi09f10 (1), zgc:136898 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in brain development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BAF chromatin remodeling complex subunit BCL11A).
Genome Resources: Alliance (1),  Gene:678650 (1),  Ensembl(GRCz11):ENSDARG00000061352 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18 Point Mutation Unknown Splice Site ENU
sa22311 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38944 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bcl11aa N/A 1
    MO2-bcl11aa N/A 1
    DISEASE ASSOCIATED WITH bcl11aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Dias-Logan syndrome 617101
    DISEASE ASSOCIATED WITH bcl11aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bcl11aa-201 (1)    Ensembl 9615
    bcl11aa-202 (1)    Ensembl 730
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bcl11aa No data available
    MARKER RELATIONSHIPS
    bcl11aa Contained in: [BAC] CH211-105K20 (1), DKEY-184B7 (1) (order this)
    bcl11aa Encodes: [EST] fi09f10
    [cDNA] MGC:136898 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040391 (1) 2967 nt
    Genomic GenBank:CR352326 (1) 174828 nt
    Select Tool
    Polypeptide UniProtKB:Q1RLR5 (1) 829 aa
    Sequence Information (all 12)
    ORTHOLOGY for bcl11aa ( Chr: 13 )
    CITATIONS (29)