ZFIN ID: ZDB-GENE-060315-10
Gene Name: solute carrier family 30 member 8
Gene Symbol: slc30a8    Nomenclature History

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Previous Names: wu:fe49g03, ZnT8 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have zinc ion transmembrane transporter activity. Involved in glucose homeostasis and type B pancreatic cell development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including RPRD1A (regulation of nuclear pre-mRNA domain containing 1A).
Genome Resources: Alliance (1),  Gene:560642 (1),  Ensembl(GRCz11):ENSDARG00000100917 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu1798 Point Mutation Exon 5 Missense ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-slc30a8 N/A 1
DISEASE ASSOCIATED WITH slc30a8 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent, susceptibility to} 125853
DISEASE ASSOCIATED WITH slc30a8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endocrine pancreas development (more)
Cellular Component integral component of membrane (more)
Molecular Function zinc ion transmembrane transporter activity (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA slc30a8-201 (1)    Ensembl 3839
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM slc30a8 No data available
MARKER RELATIONSHIPS
slc30a8 Contained in: [BAC] CH73-49O18 (1)
slc30a8 Encodes: [EST] fe49g03
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_021468284 (1)
Genomic GenBank:CU856423 (1) 117903 nt
Select Tool
Polypeptide UniProtKB:A0A0R4IFM6 (1) 388 aa
Sequence Information (all 10)
ORTHOLOGY for slc30a8 ( Chr: 19 )
CITATIONS (23)