ZFIN ID: ZDB-GENE-060303-1
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Gene Name: polymerase (DNA directed), gamma
Gene Symbol: polg
Sequence Ontology ID : SO:0000704

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
  exocrine pancreas, whole organism
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
muz119 Small Deletion Unknown Premature Stop TALEN
muz120 Small Deletion Unknown Premature Stop TALEN
muz121 Small Deletion Unknown Unknown TALEN
sa9574 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa44240 Point Mutation Unknown Splice Site ENU
    Targeting reagents: TALEN1-polg (1)
    PHENOTYPE
    Data: 5 figures from Rahn et al., 2015
    Observed in: anatomical structure, caudal fin mitochondrial chromosome, central nervous system cellular respiration, central nervous system mitochondrial chromosome (all 9) expand
    DISEASE ASSOCIATED WITH polg HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Alpers syndrome Mitochondrial DNA depletion syndrome 4A (Alpers type) 203700
    mitochondrial DNA depletion syndrome 4a Mitochondrial DNA depletion syndrome 4A (Alpers type) 203700
    mitochondrial DNA depletion syndrome 4b Mitochondrial DNA depletion syndrome 4B (MNGIE type) 613662
    Progressive external ophthalmoplegia, autosomal dominant 1 157640
    Progressive external ophthalmoplegia, autosomal recessive 1 258450
    Mitochondrial recessive ataxia syndrome (includes SANDO and SCAE) 607459
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA replication (more)
    Cellular Component gamma DNA polymerase complex (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001098 (1)
  • InterPro:IPR002297 (1)
  • InterPro:IPR012337 (1)
  • InterPro:IPR019760 (1)
    		•
  • PROSITE:PS00447 (1)
    		•
  • Pfam:PF00476 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA polg-001 (1) 4875
    Select Tool
    ncRNA polg-002 (1) 812
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-polg (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM polg No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    polgContained in: [BAC] CH211-198O8 (1) (order this), CH211-200N5 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001921095 (1) 3882bp
    Select Tool
    Genomic GenBank:CR854881 (1) 193195bp
    Select Tool
    Polypeptide UniProtKB:F8W5R6 (1) 1206aa
    Select Tool
    Sequence Clusters UniGene:151371 (1)
    Sequence Information (all 9)
    OTHER polg GENE PAGES
  • Gene:100150924 (1)
  • VEGA:OTTDARG00000035879 (1)
  • Ensembl(GRCz10):ENSDARG00000060951 (1)
    • ORTHOLOGY for polg (Chr: 25)
    CITATIONS (19)