ZFIN ID: ZDB-GENE-060303-1
Gene Name: polymerase (DNA directed), gamma
Gene Symbol: polg    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have 3'-5' exonuclease activity and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication. Predicted to localize to mitochondrion. Is expressed in exocrine pancreas. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit).
Genome Resources: Alliance (1),  Gene:100150924 (1),  Ensembl(GRCz11):ENSDARG00000060951 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
muz119 Indel Unknown Premature Stop TALEN
muz120 Small Deletion Unknown Premature Stop TALEN
muz121 Small Deletion Unknown Unknown TALEN
sa9574 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44240 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-polg
    1
    TALEN1-polg 1
    DISEASE ASSOCIATED WITH polg HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alpers-Huttenlocher syndrome Alliance Mitochondrial DNA depletion syndrome 4A (Alpers type) 203700
    autosomal dominant progressive external ophthalmoplegia 1 Alliance Progressive external ophthalmoplegia, autosomal dominant 1 157640
    autosomal recessive progressive external ophthalmoplegia 1 Alliance Progressive external ophthalmoplegia, autosomal recessive 1 258450
    mitochondrial DNA depletion syndrome 4b Alliance Mitochondrial DNA depletion syndrome 4B (MNGIE type) 613662
    sensory ataxic neuropathy, dysarthria, and ophthalmoparesis Alliance Mitochondrial recessive ataxia syndrome (includes SANDO and SCAE) 607459
    DISEASE ASSOCIATED WITH polg VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    mitochondrial metabolism disease polgmuz120/muz120 standard conditions Rahn et al., 2015
    polgmuz119/muz119 standard conditions Rahn et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA replication (more)
    Cellular Component gamma DNA polymerase complex (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA polg-202 (1)    Ensembl 4875
    ncRNA polg-002 (1)    Ensembl 812
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-polg Rabbit WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM polg No data available
    MARKER RELATIONSHIPS
    polg Contained in: [BAC] CH211-198O8 (1), CH211-200N5 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001921095 (1) 4257 nt
    Genomic GenBank:CR854881 (1) 193195 nt
    Select Tool
    Polypeptide UniProtKB:F8W5R6 (1) 1206 aa
    Sequence Information (all 8)
    ORTHOLOGY for polg ( Chr: 25 )
    CITATIONS (30)