Gene

ireb2

ID
ZDB-GENE-051205-1
Name
iron-responsive element binding protein 2
Symbol
ireb2 Nomenclature History
Previous Names
  • IRP2 (1)
  • im:7153062
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have 4 iron, 4 sulfur cluster binding activity; aconitate hydratase activity; and iron-responsive element binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to localize to cytosol and mitochondrion. Is expressed in blood and presumptive blood. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ireb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia 618451
Associated With ireb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018136 Aconitase family, 4Fe-4S cluster binding site
Domain IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
Domain IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
Family IPR006249 Aconitase/Iron-responsive element-binding protein 2
Family IPR029755 Iron regulatory protein 2
Homologous_superfamily IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
Homologous_superfamily IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
Homologous_superfamily IPR036008 Aconitase, iron-sulfur domain
Domain Details Per Protein
Protein Length Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 Aconitase/3-isopropylmalate dehydratase, swivel Aconitase A/isopropylmalate dehydratase small subunit, swivel domain Aconitase family, 4Fe-4S cluster binding site Aconitase/Iron-responsive element-binding protein 2 Aconitase, iron-sulfur domain Iron regulatory protein 2
UniProtKB:Q3YMK8 246
UniProtKB:F1QNR8 974
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations