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ZIRC
ZFIN ID: ZDB-GENE-051205-1
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Gene Name: iron-responsive element binding protein 2
Gene Symbol: ireb2    Nomenclature History

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Previous Names: IRP2 (1), im:7153062

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have 4 iron, 4 sulfur cluster binding activity; aconitate hydratase activity; and iron-responsive element binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to localize to the cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in blood and presumptive blood. Orthologous to human IREB2 (iron responsive element binding protein 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000021466 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7153062]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3307 Point Mutation Unknown Premature Stop ENU
sa5705 Point Mutation Unknown Premature Stop ENU
sa12679 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa14739 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa24600 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa44228 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ireb2 N/A 1
    MO2-ireb2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ireb2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia 618451
    DISEASE ASSOCIATED WITH ireb2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular iron ion homeostasis (more)
    Cellular Component cytoplasm (more)
    Molecular Function 4 iron, 4 sulfur cluster binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000573 (1)
  • InterPro:IPR001030 (1)
  • InterPro:IPR006249 (1)
  • InterPro:IPR015928 (1)
  • InterPro:IPR015931 (1)
  • InterPro:IPR018136 (1)
  • InterPro:IPR029755 (1)
  • InterPro:IPR036008 (1)
  • PROSITE:PS00450 (1)
  • PROSITE:PS01244 (1)
  • Pfam:PF00330 (1)
  • Pfam:PF00694 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ireb2-201 (1)    Ensembl 3091
    Select Tool
    Browsers: Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ireb2 No data available
    MARKER RELATIONSHIPS
    ireb2 Contained in: [BAC] DKEY-275P19 (1) (order this)
    ireb2 Encodes: [EST] IMAGE:7153062 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:DQ083333 (1) 740 bp
    Select Tool
    Genomic GenBank:BX296538 (1) 192787 bp
    Select Tool
    Polypeptide UniProtKB:F1QNR8 (1) 974 aa
    Select Tool
    Sequence Information (all 5)
    ORTHOLOGY for ireb2 ( Chr: 25 )
    CITATIONS (20)