Gene
ireb2
- ID
- ZDB-GENE-051205-1
- Name
- iron-responsive element binding protein 2
- Symbol
- ireb2 Nomenclature History
- Previous Names
-
- IRP2 (1)
- im:7153062
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have 4 iron, 4 sulfur cluster binding activity; aconitate hydratase activity; and iron-responsive element binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in blood and presumptive blood. Orthologous to human IREB2 (iron responsive element binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) UCSC scRNA-seq (1)
- Thisse Expression Data
-
- IMAGE:7153062 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia | 618451 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018136 | Aconitase family, 4Fe-4S cluster binding site |
| Domain | IPR000573 | Aconitase A/isopropylmalate dehydratase small subunit, swivel domain |
| Domain | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain |
| Domain | IPR044137 | Aconitase A, swivel domain |
| Family | IPR006249 | Aconitase/Iron-responsive element-binding protein 2 |
| Family | IPR029755 | Iron regulatory protein 2 |
| Homologous_superfamily | IPR015928 | Aconitase/3-isopropylmalate dehydratase, swivel |
| Homologous_superfamily | IPR015931 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 |
| Homologous_superfamily | IPR036008 | Aconitase, iron-sulfur domain |
Domain Details Per Protein
| Protein | Length | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 | Aconitase/3-isopropylmalate dehydratase, swivel | Aconitase A/isopropylmalate dehydratase small subunit, swivel domain | Aconitase A, swivel domain | Aconitase family, 4Fe-4S cluster binding site | Aconitase/Iron-responsive element-binding protein 2 | Aconitase, iron-sulfur domain | Iron regulatory protein 2 |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QNR8
|
974 | |||||||||
|
UniProtKB:Q3YMK8
|
246 |
Interactions and Pathways
No data available
Plasmids
No data available