ZFIN ID: ZDB-GENE-090908-3
Gene Name: pyruvate carboxylase a
Gene Symbol: pcxa    Nomenclature History

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Previous Names: pcl, information overload (1), PYCa (1), zgc:123047

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have pyruvate carboxylase activity. Involved in habituation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
Genome Resources: Alliance (1),  Gene:553283 (1),  Ensembl(GRCz11):ENSDARG00000098766 (1)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014043Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021930Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021931Tg Transgenic Insertion Unknown Unknown DNA
    la028335Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p171 Point Mutation Unknown Premature Stop ENU
    sa16065 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23952 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37328 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pcxa
    2
    CRISPR2-pcxa
    2
    CRISPR3-pcxa
    2
    CRISPR4-pcxa
    2
    CRISPR5-pcxa
    2
    CRISPR6-pcxa
    2
    CRISPR7-pcxa
    2
    CRISPR8-pcxa
    2
    PHENOTYPE
    Data: Fig. 1 from Wolman et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH pcxa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pyruvate carboxylase deficiency disease Alliance Pyruvate carboxylase deficiency 266150
    DISEASE ASSOCIATED WITH pcxa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process habituation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pcxa-201 (1)    Ensembl 3887
    ncRNA pcxa-003 (1)    Ensembl 1384
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcxa No data available
    MARKER RELATIONSHIPS
    pcxa Contained in: [BAC] CH73-384D19 (1), CH211-198K5 (1), CH211-201D22 (1), CH211-217F24 (1), CH211-250A23
    pcxa Encodes: [cDNA] MGC:123047 (1)
    pcxa Has Artifact: [cDNA] MGC:173742
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001037670 (1) 1385 nt
    Genomic GenBank:BX465841 (1) 190913 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IFJ4 (1) 1181 aa
    Sequence Information (all 19)
    ORTHOLOGY for pcxa ( Chr: 21 )
    CITATIONS (29)