Gene
pcxa
- ID
- ZDB-GENE-090908-3
- Name
- pyruvate carboxylase a
- Symbol
- pcxa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have pyruvate carboxylase activity. Involved in habituation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wolman et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pyruvate carboxylase deficiency disease | Alliance | Pyruvate carboxylase deficiency | 266150 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR000891 | Pyruvate carboxyltransferase |
| Domain | IPR003379 | Carboxylase, conserved domain |
| Domain | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
| Domain | IPR005481 | Biotin carboxylase-like, N-terminal domain |
| Domain | IPR005482 | Biotin carboxylase, C-terminal |
| Domain | IPR011761 | ATP-grasp fold |
| Domain | IPR011764 | Biotin carboxylation domain |
| Family | IPR005930 | Pyruvate carboxylase |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR011054 | Rudiment single hybrid motif |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR013815 | ATP-grasp fold, subdomain 1 |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Biotin-binding site | Biotin carboxylase, C-terminal | Biotin carboxylase-like, N-terminal domain | Biotin carboxylation domain | Biotin/lipoyl attachment | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Carboxylase, conserved domain | Pre-ATP-grasp domain superfamily | Pyruvate carboxylase | Pyruvate carboxyltransferase | Rudiment single hybrid motif | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IFJ4
|
1181 |
Interactions and Pathways
No data available
Plasmids
No data available