Gene

nedd4l

ID
ZDB-GENE-051118-2
Name
NEDD4 like E3 ubiquitin protein ligase
Symbol
nedd4l Nomenclature History
Previous Names
  • nedd4b (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase).
Genome Resources
Note
None
Expression
All Expression Data
from Bakkers et al., 2005
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nedd4l Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Periventricular nodular heterotopia 7 617201
Associated With nedd4l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000008 C2 domain
Domain IPR000569 HECT domain
Domain IPR001202 WW domain
Family IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR036020 WW domain superfamily
Domain Details Per Protein
Protein Length C2 domain C2 domain superfamily E3 ubiquitin-protein ligase, SMURF1 type HECT domain HECT, E3 ligase catalytic domain WW domain WW domain superfamily
UniProtKB:A0A2R8QEV4 988
UniProtKB:F1QP93 988
UniProtKB:F1Q632 1011
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations