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ZIRC
ZFIN ID: ZDB-GENE-051113-64
Gene Name: transcription factor 3b
Gene Symbol: tcf3b    Nomenclature History

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Previous Names: tcf3a (1), zgc:113045

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have several functions, including DNA-binding transcription factor activity; bHLH transcription factor binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).
Genome Resources: Alliance (1),  Gene:664768 (1),  Ensembl(GRCz11):ENSDARG00000099999 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43820 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tcf3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Agammaglobulinemia 8, autosomal dominant 616941
    DISEASE ASSOCIATED WITH tcf3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of neuron differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function protein dimerization activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • InterPro:IPR036638 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcf3b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myl7:EGFP-tcf3b-2A-Tomato) myl7 2AEGFPtcf3bTomato Danio rerio 1 1
    MARKER RELATIONSHIPS
    tcf3b Encodes: [cDNA] MGC:113045 (1) (order this), MGC:174995 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001172683 (1)
    Polypeptide UniProtKB:B1H1L4 (1) 652 aa
    Sequence Clusters UniGene:41669 (1)
    Sequence Information (all 25)
    ORTHOLOGY for tcf3b ( Chr: 22 )
    CITATIONS (18)