ZFIN Gene: tcf3b

ZFIN ID: ZDB-GENE-051113-64

ZFIN ID: ZDB-GENE-051113-64

Gene Name:

transcription factor 3b

Gene Symbol:

tcf3b Nomenclature History

Previous Names:

tcf3a (1), zgc:113045

Gene Type:

protein_coding_gene

Location:

Chr: 22 Mapping Details/Browsers

Description:

Predicted to have several functions, including DNA-binding transcription factor activity; bHLH transcription factor binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus and transcription regulator complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).

Genome Resources:

Alliance (1), Gene:664768 (1), Ensembl(GRCz11):ENSDARG00000099999 (1)

GENE EXPRESSION
All Expression Data:	2 figures from 2 publications
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
	whole organism
High Throughput Expression:	Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa43820	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH tcf3b HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Agammaglobulinemia 8, autosomal dominant	616941

DISEASE ASSOCIATED WITH tcf3b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	positive regulation of neuron differentiation (more)
Cellular Component	nucleus (more)
Molecular Function	protein dimerization activity (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS No data available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM tcf3b

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(myl7:EGFP-tcf3b-2A-Tomato)	myl7	2A, EGFP, tcf3b, Tomato	Danio rerio	1	1

MARKER RELATIONSHIPS

tcf3b Encodes:

[cDNA] MGC:113045 (1), MGC:174995 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001172683 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Polypeptide	UniProtKB:B1H1L4 (1)	652 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 24)

ORTHOLOGY for tcf3b ( Chr: 22 )

CITATIONS (20)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: