ZFIN ID: ZDB-GENE-050916-2
Gene Name: KIT proto-oncogene, receptor tyrosine kinase b
Gene Symbol: kitb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including Kit signaling pathway; hemopoiesis; and positive regulation of signal transduction. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Is expressed in several structures, including male organism; mucus secreting cell; nervous system; otic vesicle; and ventral mesoderm. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).
Genome Resources: Alliance (1),  Gene:497629 (1),  Ensembl(GRCz11):ENSDARG00000056133 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9136 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15348 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32649 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko370a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko370b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kitb 1
    MO1-kitb N/A 1
    MO2-kitb N/A 1
    DISEASE ASSOCIATED WITH kitb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
    gastrointestinal stromal tumor Alliance Gastrointestinal stromal tumor, familial 606764
    mastocytosis Alliance Mastocytosis, cutaneous 154800
    Mastocytosis, systemic, somatic 154800
    piebaldism Alliance Piebaldism 172800
    testicular germ cell cancer Alliance Germ cell tumors, somatic 273300
    DISEASE ASSOCIATED WITH kitb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic hemopoiesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Family IPR027263 Mast/stem cell growth factor receptor
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kitb-201 (1)    Ensembl 2903
    ncRNA kitb-002 (1)    Ensembl 996
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-kitb monoclonal Mouse IHC 1
    CONSTRUCTS WITH SEQUENCES FROM kitb No data available
    MARKER RELATIONSHIPS
    kitb Contained in: [BAC] DKEY-245P14 (1) (order this)
    kitb Encodes: [cDNA] cssl:d836 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001143918 (1) 2930 bp
    Genomic GenBank:BX548248 (1) 195620 bp
    Select Tool
    Polypeptide UniProtKB:B8A5K6 (1) 957 aa
    Sequence Information (all 19)
    ORTHOLOGY for kitb ( Chr: 1 )
    CITATIONS (33)