ZFIN ID: ZDB-GENE-050913-98
Gene Name: S-antigen; retina and pineal gland (arrestin) b
Gene Symbol: sagb    Nomenclature History

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Previous Names: sag, Arrestin Sb (1), zgc:114197

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor binding activity. Predicted to be involved in G protein-coupled receptor internalization. Predicted to localize to photoreceptor inner segment and photoreceptor outer segment. Is expressed in epiphysis; eye; photoreceptor cell; retina; and retinal outer nuclear layer. Human ortholog(s) of this gene implicated in Oguchi disease-1; hereditary night blindness; and retinitis pigmentosa 47. Orthologous to human SAG (S-antigen visual arrestin).
Genome Resources: Alliance (1),  Gene:619268 (1),  Ensembl(GRCz11):ENSDARG00000038378 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22731 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36002 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sagb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Oguchi disease-1 Alliance Oguchi disease-1 258100
    retinitis pigmentosa 47 Alliance Retinitis pigmentosa 47 613758
    DISEASE ASSOCIATED WITH sagb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Cellular Component photoreceptor inner segment (more)
    Molecular Function G protein-coupled receptor binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript sagb-202 (1)    Ensembl 582
    mRNA sagb-203 (1)    Ensembl 1088
    sagb-204 (1)    Ensembl 733
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-sag monoclonal Mouse IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sagb No data available
    MARKER RELATIONSHIPS
    sagb Contained in: [Fosmid] CH1073-430K5 (1)
    sagb Encodes: [cDNA] MGC:114197 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001033749 (1) 894 nt
    Genomic GenBank:CU672237 (1) 35259 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ISJ7 (1) 385 aa
    Sequence Information (all 15)
    ORTHOLOGY for sagb ( Chr: 15 )
    CITATIONS (21)