ZFIN ID: ZDB-GENE-050913-68
Gene Name: F-box protein 7
Gene Symbol: fbxo7    Nomenclature History

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Previous Names: si:ch211-286m4.2, zgc:114096

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have protein kinase binding activity. Involved in musculoskeletal movement. Is expressed in brain; heart; and liver. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7).
Genome Resources: Alliance (1),  Gene:558097 (1),  Ensembl(GRCz11):ENSDARG00000099833 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:114096]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1523 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-fbxo7 N/A 1
MO2-fbxo7 N/A 1
DISEASE ASSOCIATED WITH fbxo7 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 15 Alliance Parkinson disease 15, autosomal recessive 260300
DISEASE ASSOCIATED WITH fbxo7 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process musculoskeletal movement (more)
Cellular Component cellular_component (more)
Molecular Function protein kinase binding (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA fbxo7-201 (1)    Ensembl 1721
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-fbxo7 polyclonal Mouse IHC, WB Abnova
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM fbxo7 No data available
MARKER RELATIONSHIPS
fbxo7 Contained in: [BAC] CH73-4I5 (1), CH211-286M4 (1)
fbxo7 Encodes: [cDNA] MGC:114096 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001025499 (1) 1743 nt
Genomic GenBank:AL845512 (1) 192940 nt
Select Tool
Polypeptide UniProtKB:Q4V8X6 (1) 486 aa
Sequence Information (all 12)
ORTHOLOGY for fbxo7 ( Chr: 4 )
CITATIONS (17)