ZFIN ID: ZDB-GENE-050913-65
Gene Name: F-box and leucine-rich repeat protein 18
Gene Symbol: fbxl18    Nomenclature History

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Previous Name: zgc:114102

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to contribute to ubiquitin protein ligase activity. Involved in sclerotome development. Predicted to localize to the SCF ubiquitin ligase complex; cytosol; and nucleus. Orthologous to human FBXL18 (F-box and leucine rich repeat protein 18).
Genome Resources: Alliance (1),  Gene:570298 (1),  Ensembl(GRCz11):ENSDARG00000007443 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:114102]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa767 Point Mutation Unknown Premature Stop ENU
sa9554 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19420 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39545 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fbxl18 N/A 1
    PHENOTYPE
    Data: Fig. 5 from Lee et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH fbxl18 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fbxl18 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sclerotome development (more)
    Cellular Component cytosol (more)
    Molecular Function CONTRIBUTES_TO   ubiquitin protein ligase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001810 F-box domain
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fbxl18-201 (1)    Ensembl 2626
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fbxl18 No data available
    MARKER RELATIONSHIPS
    fbxl18 Contained in: [BAC] CH211-160D14 (1)
    fbxl18 Encodes: [cDNA] MGC:114102 (1), MGC:162850 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001030245 (1) 2631 bp
    Genomic GenBank:AL928650 (1) 178563 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8S0B5 (1) 721 aa
    Sequence Information (all 13)
    ORTHOLOGY for fbxl18 ( Chr: 1 )
    CITATIONS (18)