ZFIN ID: ZDB-GENE-050904-6
Gene Name: mannose phosphate isomerase
Gene Symbol: mpi    Nomenclature History

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Previous Names: im:7140016, zgc:110773

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits mannose-6-phosphate isomerase activity. Involved in chondrocyte morphogenesis; chordate embryonic development; and liver development. Predicted to localize to cytosol. Is expressed in several structures, including female organism; margin; nervous system; neural tube; and polster. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase).
Genome Resources: Alliance (1),  Gene:613246 (1),  Ensembl(GRCz11):ENSDARG00000030786 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [IMAGE:7140016]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mss7 Indel Exon 2 Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mpi N/A 4
TALEN1-mpi 1
DISEASE ASSOCIATED WITH mpi HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital disorder of glycosylation Ib Alliance Congenital disorder of glycosylation, type Ib 602579
DISEASE ASSOCIATED WITH mpi VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
congenital disorder of glycosylation type I AB + MO1-mpi standard conditions Chu et al., 2013
GENE ONTOLOGY
Ontology GO Term
Biological Process chondrocyte morphogenesis (more)
Cellular Component cytosol (more)
Molecular Function mannose-6-phosphate isomerase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mpi-201 (1)    Ensembl 1503
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mpi No data available
MARKER RELATIONSHIPS
mpi Contained in: [Fosmid] CH1073-232C9 (1), CH1073-296I8 (1)
mpi Encodes: [EST] IMAGE:7140016 (1)
[cDNA] MGC:110773 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001033110 (1) 1520 nt
Genomic GenBank:CU651670 (1) 38908 nt
Select Tool
Polypeptide UniProtKB:Q3ZB95 (1) 422 aa
Sequence Information (all 12)
ORTHOLOGY for mpi ( Chr: 25 )
CITATIONS (30)