Gene

mpi

ID
ZDB-GENE-050904-6
Name
mannose phosphate isomerase
Symbol
mpi Nomenclature History
Previous Names
  • im:7140016
  • zgc:110773
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Exhibits mannose-6-phosphate isomerase activity. Involved in chondrocyte morphogenesis; chordate embryonic development; and liver development. Predicted to localize to cytosol. Is expressed in several structures, including female organism; margin; nervous system; neural tube; and polster. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mpi Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital disorder of glycosylation Ib Alliance Congenital disorder of glycosylation, type Ib 602579
Associated With mpi Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018050 Phosphomannose isomerase, type I, conserved site
Family IPR001250 Mannose-6-phosphate isomerase, type I
Family IPR016305 Mannose-6-phosphate isomerase
Homologous_superfamily IPR011051 RmlC-like cupin domain superfamily
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Domain Details Per Protein
Protein Length Mannose-6-phosphate isomerase Mannose-6-phosphate isomerase, type I Phosphomannose isomerase, type I, conserved site RmlC-like cupin domain superfamily RmlC-like jelly roll fold
UniProtKB:Q3ZB95 422
UniProtKB:A0A2R8QRD7 372
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations