celsr1b

ID

ZDB-GENE-050823-4

Name

cadherin EGF LAG seven-pass G-type receptor 1b

Symbol

celsr1b Nomenclature History

Previous Names

celsr5
fmi1b (1)
flamingo 1b (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within cell migration involved in gastrulation; heart development; and neural tube development. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; eye; notochord; pleuroperitoneal region; and spinal cord neural tube. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With celsr1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Lymphatic malformation 9	619319

Associated With celsr1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR002126	Cadherin-like
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR056286	CELSR1-3-like, ninth cadherin domain
Family	IPR000832	GPCR, family 2, secretin-like
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015919	Cadherin-like superfamily
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily