ZFIN ID: ZDB-GENE-050729-1
Gene Name: neural retina leucine zipper
Gene Symbol: nrl    Nomenclature History

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Previous Name: zgc:136315

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in lens; retina; retinal outer nuclear layer; and solid lens vesicle. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 27. Orthologous to human NRL (neural retina leucine zipper).
Genome Resources: Alliance (1),  Gene:554169 (1),  Ensembl(GRCz11):ENSDARG00000100466 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43363 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nrl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 27 Alliance Retinitis pigmentosa 27 613750
    Retinal degeneration, autosomal recessive, clumped pigment type
    DISEASE ASSOCIATED WITH nrl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component host cell nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nrl No data available
    MARKER RELATIONSHIPS
    nrl Encodes: [cDNA] MGC:136315 (1), MGC:194187 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040331 (1)
    Genomic GenBank:FO904888 (1) 35350 nt
    Select Tool
    Polypeptide UniProtKB:Q1RM92 (1) 412 aa
    Sequence Information (all 15)
    ORTHOLOGY for nrl ( Chr: 20 )
    CITATIONS (24)