ZFIN ID: ZDB-GENE-050714-2
Gene Name: cytochrome P450, family 26, subfamily C, polypeptide 1
Gene Symbol: cyp26c1    Nomenclature History

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Previous Names: cyp26b1l, cyp26d1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in several processes, including circulatory system development; retinoic acid metabolic process; and rhombomere 4 morphogenesis. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Is expressed in several structures, including brain; eye; hindbrain neural keel; optic cup; and pleuroperitoneal region. Orthologous to human CYP26C1 (cytochrome P450 family 26 subfamily C member 1).
Genome Resources: Alliance (1),  Gene:554036 (1),  Ensembl(GRCz11):ENSDARG00000056029 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tpl24Gt Transgenic Insertion Unknown Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-cyp26c1
1
CRISPR2-cyp26c1
1
MO1-cyp26c1 N/A 7
MO2-cyp26c1 N/A 4
MO3-cyp26c1 N/A 1
MO4-cyp26c1 N/A 2
DISEASE ASSOCIATED WITH cyp26c1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Focal facial dermal dysplasia 4 614974
DISEASE ASSOCIATED WITH cyp26c1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process retinoic acid metabolic process (more)
Molecular Function heme binding (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Family IPR002403 Cytochrome P450, E-class, group IV
Conserved_site IPR017972 Cytochrome P450, conserved site
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
antisense ottdart00000055385 (1) 497
mRNA cyp26c1-201 (1)    Ensembl 4032
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cyp26c1 No data available
MARKER RELATIONSHIPS
cyp26c1 Contained in: [BAC] DKEY-71B20 (1) (order this)
cyp26c1 Encodes: [cDNA] MGC:158120 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001029951 (1) 4034 bp
Genomic GenBank:CU571091 (1) 75771 bp
Select Tool
Polypeptide UniProtKB:A1L1M2 (1) 554 aa
Sequence Information (all 13)
ORTHOLOGY for cyp26c1 ( Chr: 17 )
CITATIONS (57)