ZFIN ID: ZDB-GENE-050531-1
Gene Name: myosin, heavy chain 11a, smooth muscle
Gene Symbol: myh11a    Nomenclature History

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Previous Names: myh11, meltdown, mlt, smmhc (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including digestive tract morphogenesis; heart contraction; and regulation of polarized epithelial cell differentiation. Predicted to localize to the myosin complex. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in patent ductus arteriosus and thoracic aortic aneurysm. Is expressed in gut and muscle. Orthologous to human MYH11 (myosin heavy chain 11).
Genome Resources: Alliance (1),  Gene:554168 (1),  Ensembl(GRCz11):ENSDARG00000009782 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m498 Point Mutation Unknown Unknown ENU
p318 Point Mutation Unknown Missense ENU
p319 Point Mutation Unknown Missense ENU
sa7029 Point Mutation Unknown Premature Stop ENU
sa11268 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15692 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16661 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16962 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20640 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20641 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20642 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40634 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myh11a
    1
    CRISPR2-myh11a
    1
    MO1-myh11a N/A 3
    DISEASE ASSOCIATED WITH myh11a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 4 132900
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood circulation (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002928 Myosin tail
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myh11a-201 (1)    Ensembl 7086
    myh11a-202 (1)    Ensembl 531
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-myh11 polyclonal IgG Rabbit IHC, WB Biomedical Technologies, Inc.
    9
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myh11a No data available
    MARKER RELATIONSHIPS
    myh11a Contained in: [BAC] DKEY-217D24 (1) (order this)
    myh11a Encodes: [cDNA] MGC:193666 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001024448 (1) 7109 bp
    Genomic GenBank:CR388009 (1) 223237 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DFS9 (1) 1974 aa
    Sequence Information (all 16)
    ORTHOLOGY for myh11a ( Chr: 6 )
    CITATIONS (43)