Gene

myh11a

ID
ZDB-GENE-050531-1
Name
myosin, heavy chain 11a, smooth muscle
Symbol
myh11a Nomenclature History
Previous Names
  • myh11
  • meltdown
  • mlt
  • smmhc (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in several processes, including digestive tract morphogenesis; heart contraction; and regulation of polarized epithelial cell differentiation. Predicted to localize to myosin complex. Is expressed in gut and muscle. Used to study megacystis-microcolon-intestinal hypoperistalsis syndrome. Human ortholog(s) of this gene implicated in patent ductus arteriosus and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myh11a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 4 132900
Megacystis-microcolon-intestinal hypoperistalsis syndrome 2 619351
Visceral myopathy 2 619350
Associated With myh11a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q4U0S2 1974
UniProtKB:E9QEW5 133
UniProtKB:B3DFS9 1974
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-myh11 polyclonal IgG Rabbit
  • IHC
  • WB
Biomedical Technologies, Inc.
10
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations