ZFIN ID: ZDB-GENE-050522-75
Gene Name: nucleoredoxin
Gene Symbol: nxn    Nomenclature History

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Previous Names: ns:zf-es94, zgc:110449

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have protein-disulfide reductase activity. Predicted to be involved in cardiovascular system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including basal plate midbrain region; brain; immature eye; lens; and neural plate. Human ortholog(s) of this gene implicated in Robinow syndrome. Orthologous to human NXN (nucleoredoxin).
Genome Resources: Alliance (1),  Gene:553621 (1),  Ensembl(GRCz11):ENSDARG00000033978 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012674Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la019168Tg Transgenic Insertion Unknown Unknown DNA
    sa16536 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35837 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nxn HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Robinow syndrome, autosomal recessive 2 618529
    DISEASE ASSOCIATED WITH nxn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardiovascular system development (more)
    Cellular Component cytoplasm (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nxn-201 (1)    Ensembl 2478
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nxn No data available
    MARKER RELATIONSHIPS
    nxn Contained in: [BAC] CH211-259G3 (1), DKEY-179C2 (1) (order this)
    nxn Contains: [SNP] rs3728701 (1), rs3728702 (1), rs3728703 (1)
    nxn Encodes: [EST] zf-es94 (1)
    [cDNA] MGC:110449 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020595 (1) 2231 nt
    Genomic GenBank:AL954372 (1) 162539 nt
    Select Tool
    Polypeptide UniProtKB:F1R5G2 (1) 418 aa
    Sequence Information (all 15)
    ORTHOLOGY for nxn ( Chr: 15 )
    CITATIONS (31)