Gene

nxn

ID
ZDB-GENE-050522-75
Name
nucleoredoxin
Symbol
nxn Nomenclature History
Previous Names
  • ns:zf-es94
  • zgc:110449
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have protein-disulfide reductase activity. Predicted to be involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to localize to cytosol and nucleus. Is expressed in several structures, including basal plate midbrain region; brain; immature eye; lens; and neural plate. Human ortholog(s) of this gene implicated in Robinow syndrome. Orthologous to human NXN (nucleoredoxin).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nxn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Robinow syndrome, autosomal recessive 2 618529
Associated With nxn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR012336 Thioredoxin-like fold
Domain IPR013766 Thioredoxin domain
Domain IPR041861 Nucleoredoxin, redox inactive TRX-like domain b'
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Nucleoredoxin, redox inactive TRX-like domain b' Thioredoxin domain Thioredoxin-like fold Thioredoxin-like superfamily
UniProtKB:Q503L9 418
UniProtKB:A0A2R8Q546 316
UniProtKB:F1R5G2 418
UniProtKB:A0A2R8Q274 366
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations