ZFIN ID: ZDB-GENE-050522-308
Gene Name: SIX homeobox 6b
Gene Symbol: six6b    Nomenclature History

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Previous Names: si:dkey-225h23.3, zgc:110344

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in cell proliferation involved in compound eye morphogenesis. Predicted to localize to the nucleus and transcription factor complex. Is expressed in hypothalamus. Orthologous to human SIX6 (SIX homeobox 6).
Genome Resources: Alliance (1),  Gene:553611 (1),  Ensembl(GRCz11):ENSDARG00000031316 (2)
GENE EXPRESSION
All Expression Data: Fig. 4 from Armant et al., 2013
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-six6b N/A 1
MO2-six6b N/A 2
MO3-six6b N/A 1
DISEASE ASSOCIATED WITH six6b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
optic disc anomalies with retinal and/or macular dystrophy Alliance Optic disc anomalies with retinal and/or macular dystrophy 212550
DISEASE ASSOCIATED WITH six6b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process camera-type eye development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
Family IPR032947 Homeobox protein SIX6
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA six6b-201 (1)    Ensembl 1615
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM six6b No data available
MARKER RELATIONSHIPS
six6b Contained in: [BAC] DKEY-225H23 (1) (order this)
six6b Encodes: [cDNA] MGC:110344 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001020585 (1) 1615 nt
Genomic GenBank:BX649231 (1) 153569 nt
Select Tool
Polypeptide UniProtKB:Q5TYZ2 (1) 245 aa
Sequence Information (all 12)
ORTHOLOGY for six6b ( Chr: 20 )
CITATIONS (30)