ZFIN ID: ZDB-GENE-050522-257
Gene Name: zeta-chain (TCR) associated protein kinase
Gene Symbol: zap70
Previous Name: zgc:110383
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
  gut T cell, whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21262 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-zap70 (1), MO2-zap70 (1)
    PHENOTYPE
    Data: 3 figures from Christie et al., 2010
    Observed in: cell migration involved in sprouting angiogenesis, dorsal longitudinal anastomotic vessel, intersegmental vessel, thoracic duct
    DISEASE ASSOCIATED WITH zap70 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Selective T-cell defect 269840
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lymphangiogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR012234 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR023420 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.2 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA zap70-001 (1) 2550
    zap70-002 (1) 727
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-zap70 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM zap70 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    zap70Contained in: [BAC] DKEY-45M5 (1) (order this)
    zap70Encodes: [cDNA] MGC:110383 (1) (order this), MGC:192552 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020589 (1) 2537bp
    Genomic GenBank:BX511253 (1) 216373bp Blast at MegaBLAST
    Polypeptide UniProtKB:M9MM92 (1) 604aa
    Sequence Clusters UniGene:14214 (1)
    Sequence Information (all 14)
    OTHER zap70 GENE PAGES
  • Gene:553615 (1)
  • VEGA:OTTDARG00000022181 (1)
  • Ensembl(GRCz10):ENSDARG00000015752 (1)
  • ORTHOLOGY for zap70 (Chr: 8)
    Species Symbol Chromosome Accession # Evidence
    Human ZAP70 2
  • Gene:7535
  • OMIM:176947
  • HGNC:12858
  • Amino acid sequence comparison (2)
    Mouse Zap70 1
  • MGI:99613
  • Gene:22637
  • Amino acid sequence comparison (2)
    Download Curated Orthology
    CITATIONS (19)