Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-050522-257
Gene Name: zeta-chain (TCR) associated protein kinase
Gene Symbol: zap70
Previous Name: zgc:110383
Location: Chr: 8   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. 4 from Christie et al., 2010
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Segmentation:20-25 somites (19.0h-22.0h)
  whole organism
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa21262
Knockdown reagents: MO1-zap70 (1), MO2-zap70 (1)
PHENOTYPE
Data: 3 figures from Christie et al., 2010
Observed in: cell migration involved in sprouting angiogenesis, dorsal longitudinal anastomotic vessel, intersegmental vessel, thoracic duct

Phenotype of Human Orthologue OMIM Phenotype ID
Selective T-cell defect 269840
GENE ONTOLOGY
Ontology GO Term
Biological Process lymphangiogenesis (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR012234 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR023420 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50001 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00017 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.2 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA zap70-001 (1) 2550
    zap70-002 (1) 727
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM zap70 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    zap70 Contained in: [BAC] DKEY-45M5 (1)
    zap70 Encodes: [cDNA] MGC:110383 (1) (order this), MGC:192552 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020589 (1) 2537 bp
    Genomic GenBank:BX511253 (1) 216373 bp Blast at MegaBLAST
    Polypeptide UniProtKB:M9MM92 (1) 604 aa
    Sequence Clusters UniGene:14214 (1)
    Sequence Information (all 14)
    OTHER zap70 GENE PAGES
  • Gene:553615 (1)
  • VEGA:OTTDARG00000022181 (1)
  • Ensembl(Zv9):ENSDARG00000015752 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish zap70 8  
    Human ZAP70 2 (2q12)
  • OMIM:176947
  • Gene:7535
  • Mouse Zap70 1 ( 15.41 cM)
  • MGI:99613
  • Gene:22637
  • Orthology Details
    CITATIONS (15)