ZFIN ID: ZDB-GENE-050522-257
Gene Name: zeta chain of T cell receptor associated protein kinase 70
Gene Symbol: zap70    Nomenclature History

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Previous Name: zgc:110383

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to localize to cytoplasm. Is expressed in gut. Human ortholog(s) of this gene implicated in primary immunodeficiency disease and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).
Genome Resources: Alliance (1),  Gene:553615 (1),  Ensembl(GRCz11):ENSDARG00000015752 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21262 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • y442 Small Deletion Exon 2 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-zap70 N/A 1
    MO2-zap70 N/A 1
    TALEN1-zap70 1
    DISEASE ASSOCIATED WITH zap70 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Autoimmune disease, multisystem, infantile-onset, 2 617006
    Immunodeficiency 48 269840
    DISEASE ASSOCIATED WITH zap70 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lymphangiogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zap70-201 (1)    Ensembl 2550
    zap70-202 (1)    Ensembl 727
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-zap70 monoclonal IgG Rabbit IHC Cell Signaling Technology, Inc.
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zap70 No data available
    MARKER RELATIONSHIPS
    zap70 Contained in: [BAC] DKEY-45M5 (1) (order this)
    zap70 Encodes: [cDNA] MGC:110383 (1), MGC:192552 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020589 (1) 2537 nt
    Genomic GenBank:BX511253 (1) 216373 nt Blast at MegaBLAST
    Polypeptide UniProtKB:M9MM92 (1) 604 aa
    Sequence Information (all 14)
    ORTHOLOGY for zap70 ( Chr: 8 )
    CITATIONS (25)