ZFIN ID: ZDB-GENE-050522-228
Gene Name: FCH and mu domain containing endocytic adaptor 2
Gene Symbol: fcho2    Nomenclature History

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Previous Names: cb304 (1), sb:cb304, si:ch211-195c22.1, wu:fa01a02, zgc:112167

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have cytoskeletal protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and phosphatidylserine binding activity. Involved in chordate embryonic development. Predicted to localize to clathrin-coated pit; clathrin-coated vesicle; and cytoskeleton. Is expressed in anterior axial hypoblast; hatching gland; immature eye; polster; and yolk syncytial layer. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2).
Genome Resources: Alliance (1),  Gene:553949 (1),  Ensembl(GRCz11):ENSDARG00000035389 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2001 [cb304]
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33648 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fcho2 N/A 1
    PHENOTYPE
    Data: Fig. S5 from Umasankar et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH fcho2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fcho2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component clathrin-coated pit (more)
    Molecular Function phosphatidylinositol-4,5-bisphosphate binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fcho2-202 (1)    Ensembl 4099
    fcho2-203 (1)    Ensembl 3291
    fcho2-204 (1)    Ensembl 259
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fcho2 No data available
    MARKER RELATIONSHIPS
    fcho2 Contained in: [BAC] CH211-195C22 (1)
    fcho2 Encodes: [EST] cb304 (1) (order this), fa01a02 (1)
    [cDNA] MGC:112167 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020781 (1) 2922 nt
    Genomic GenBank:CR377210 (1) 170134 nt
    Select Tool
    Polypeptide UniProtKB:F1RDR3 (1) 848 aa
    Sequence Information (all 39)
    ORTHOLOGY for fcho2 ( Chr: 5 )
    CITATIONS (20)