ZFIN ID: ZDB-GENE-050522-191
Gene Name: actin-like 6B
Gene Symbol: actl6b    Nomenclature History

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Previous Name: zgc:110167

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity. Predicted to be involved in chromatin organization; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to localize to NuA4 histone acetyltransferase complex and SWI/SNF complex. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Orthologous to human ACTL6B (actin like 6B).
Genome Resources: Alliance (1),  Gene:553775 (1),  Ensembl(GRCz11):ENSDARG00000034107 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110167]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37795 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-actl6b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH actl6b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Epileptic encephalopathy, early infantile, 76 618468
    Intellectual developmental disorder with severe speech and ambulation defects 618470
    DISEASE ASSOCIATED WITH actl6b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ATP-dependent chromatin remodeling (more)
    Cellular Component NuA4 histone acetyltransferase complex (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA actl6b-202 (1)    Ensembl 1592
    si:ch1073-228j22.3-001 (1) 1281
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM actl6b No data available
    MARKER RELATIONSHIPS
    actl6b Contained in: [BAC] CH73-375G18 (1)
    [Fosmid] CH1073-228J22 (1)
    actl6b Has Artifact: [cDNA] MGC:110167 (1), MGC:191648 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020740 (1) 1407 nt
    Genomic GenBank:CU896563 (1) 50535 nt
    Select Tool
    Polypeptide UniProtKB:F8W3Z2 (1) 426 aa
    Sequence Information (all 14)
    ORTHOLOGY for actl6b ( Chr: 23 )
    CITATIONS (16)