ZFIN ID: ZDB-GENE-050522-133
Gene Name: cytochrome c oxidase subunit 5Aa
Gene Symbol: cox5aa    Nomenclature History

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Previous Names: cox5a1 (1), cox5a, cb739 (1), wu:fj32b09, zgc:109989, zgc:114165

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits cytochrome-c oxidase activity. Involved in embryonic organ development and spinal cord motor neuron differentiation. Predicted to localize to mitochondrial respiratory chain complex IV. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; musculature system; and nervous system. Used to study ciliopathy and visceral heterotaxy. Orthologous to human COX5A (cytochrome c oxidase subunit 5A).
Genome Resources: Alliance (1),  Gene:554101 (1),  Ensembl(GRCz11):ENSDARG00000088383 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-cox5aa N/A 2
DISEASE ASSOCIATED WITH cox5aa HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cox5aa VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
visceral heterotaxy WT + MO1-cox5aa standard conditions Burkhalter et al., 2019
ciliopathy WT + MO1-cox5aa standard conditions Burkhalter et al., 2019
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic organ development (more)
Cellular Component mitochondrial inner membrane (more)
Molecular Function cytochrome-c oxidase activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cox5aa-201 (1)    Ensembl 690
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cox5aa No data available
MARKER RELATIONSHIPS
cox5aa Contained in: [BAC] CH211-67P11 (1)
cox5aa Contains: [STS] chunp30169
cox5aa Encodes: [EST] cb739 (1) (order this), fj32b09
[cDNA] MGC:109989 (1), MGC:114165 (1), MGC:191452 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001024403 (1) 677 nt
Genomic GenBank:CR376821 (1) 187216 nt
Select Tool
Polypeptide UniProtKB:Q4VBU7 (1) 141 aa
Sequence Information (all 22)
ORTHOLOGY for cox5aa ( Chr: 25 )
CITATIONS (27)