ZFIN ID: ZDB-GENE-050522-131
Gene Name: NADH:ubiquinone oxidoreductase core subunit S8b
Gene Symbol: ndufs8b    Nomenclature History

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Previous Name: zgc:109991 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in aerobic respiration; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Predicted to localize to mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8).
Genome Resources: Alliance (1),  Gene:554100 (1),  Ensembl(GRCz11):ENSDARG00000057055 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109991]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa28298 Point Mutation Unknown Unknown ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ndufs8b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mitochondrial complex I deficiency, nuclear type 2 618222
DISEASE ASSOCIATED WITH ndufs8b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component membrane (more)
Molecular Function 4 iron, 4 sulfur cluster binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
pseudogenic transcript ndufs8b-202 (1)    Ensembl 1002
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ndufs8b No data available
MARKER RELATIONSHIPS
ndufs8b Contained in: [BAC] DKEY-83D4 (1) (order this)
ndufs8b Encodes: [cDNA] MGC:109991 (1), MGC:192506 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001024402 (1) 1043 nt
Genomic GenBank:CT955967 (1) 131912 nt
Select Tool
Polypeptide UniProtKB:B2GS87 (1) 210 aa
Sequence Information (all 19)
ORTHOLOGY for ndufs8b ( Chr: 14 )
CITATIONS (19)