ZFIN ID: ZDB-GENE-050522-125
Gene Name: sialidase 4
Gene Symbol: neu4    Nomenclature History

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Previous Name: zgc:109998

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits exo-alpha-sialidase activity. Involved in ganglioside metabolic process. Localizes to endoplasmic reticulum. Is expressed in several structures, including heart; integument; lens; pleuroperitoneal region; and solid lens vesicle. Orthologous to human NEU4 (neuraminidase 4).
Genome Resources: Alliance (1),  Gene:553569 (1),  Ensembl(GRCz11):ENSDARG00000057677 (1)
GENE EXPRESSION
All Expression Data: 10 figures from 3 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [MGC:109998]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35789 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH neu4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH neu4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ganglioside metabolic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function exo-alpha-sialidase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA neu4-201 (1)    Ensembl 1411
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM neu4 No data available
    MARKER RELATIONSHIPS
    neu4 Contained in: [Fosmid] CH1073-371N23 (1)
    neu4 Encodes: [cDNA] MGC:109998 (1), MGC:192658 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020548 (1) 1438 nt
    Genomic GenBank:CU694447 (1) 34245 nt
    Select Tool
    Polypeptide UniProtKB:Q503Z4 (1) 429 aa
    Sequence Information (all 14)
    ORTHOLOGY for neu4 ( Chr: 15 )
    CITATIONS (19)