ZFIN ID: ZDB-GENE-050420-354
Gene Name: cyclin D2, b
Gene Symbol: ccnd2b    Nomenclature History

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Previous Name: si:ch211-240j22.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to contribute to protein kinase activity. Predicted to be involved in mitotic cell cycle phase transition; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to localize to the cyclin-dependent protein kinase holoenzyme complex; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; invasive lobular carcinoma; prostate cancer; and transitional cell carcinoma. Orthologous to human CCND2 (cyclin D2).
Genome Resources: Alliance (1),  Gene:565038 (1), 
GENE EXPRESSION
All Expression Data: Fig. 5 from Grainger et al., 2016
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ccnd2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 615938
DISEASE ASSOCIATED WITH ccnd2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process mitotic cell cycle phase transition (more)
Cellular Component nucleus (more)
Molecular Function cyclin-dependent protein serine/threonine kinase regulator activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR004367 Cyclin, C-terminal domain
Domain IPR006671 Cyclin, N-terminal
Domain IPR013763 Cyclin-like
Family IPR015451 Cyclin D
Homologous_superfamily IPR036915 Cyclin-like superfamily
Family IPR039361 Cyclin
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ccnd2b-201 (1)    Ensembl 2538
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ccnd2b No data available
MARKER RELATIONSHIPS
ccnd2b Contained in: [BAC] CH211-240J22 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001045068 (1) 888 bp
Genomic GenBank:CR751235 (1) 104632 bp
Select Tool
Polypeptide UniProtKB:Q1L8M6 (1) 295 aa
Sequence Information (all 10)
ORTHOLOGY for ccnd2b ( Chr: 4 )
CITATIONS (18)