ZFIN ID: ZDB-GENE-050420-170
Gene Name: doublecortin-like kinase 2a
Gene Symbol: dclk2a    Nomenclature History

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Previous Names: cb572 (1), dclk2, zDCLK (1), sb:cb572, si:dkey-180n16.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits protein serine/threonine kinase activity. Involved in hyperosmotic response and protein autophosphorylation. Localizes to microtubule cytoskeleton; nucleus; and synaptic vesicle. Is expressed in several structures, including hindbrain neural plate; immature eye; nervous system; optic primordium; and trigeminal placode. Orthologous to human DCLK2 (doublecortin like kinase 2).
Genome Resources: Alliance (1),  Gene:572548 (1),  Ensembl(GRCz11):ENSDARG00000034093 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7382 Point Mutation Unknown Missense ENU
sa13063 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25622 Point Mutation Unknown Splice Site ENU
    sa39646 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dclk2a N/A 1
    PHENOTYPE
    Data: 2 figures from Shimomura et al., 2007
    Observed in:
    DISEASE ASSOCIATED WITH dclk2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dclk2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hyperosmotic response (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein kinase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dclk2a-201 (1)    Ensembl 2294
    dclk2a-205 (1)    Ensembl 2333
    dclk2a-207 (1)    Ensembl 2490
    dclk2a-211 (1)    Ensembl 2406
    ncRNA dclk2a-005 (1)    Ensembl 635
    dclk2a-006 (1)    Ensembl 486
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dclk2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(Xla.Eef1a1:dclk2a-GFP) dclk2aGFP Danio rerioXenopus laevis 1 15
    Tg(Xla.Eef1a1:dclk2DeltaK-GFP) dclk2aGFP Danio rerioXenopus laevis 1 5
    MARKER RELATIONSHIPS
    dclk2a Contained in: [BAC] DKEY-180N16 (1) (order this)
    dclk2a Encodes: [EST] cb572 (1) (order this)
    [cDNA] MGC:174949 (1), MGC:195357 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001081693 (1) 2729 nt
    Genomic GenBank:BX005385 (1) 159174 nt
    Select Tool
    Polypeptide UniProtKB:A2A121 (1) 810 aa
    Sequence Information (all 48)
    ORTHOLOGY for dclk2a ( Chr: 1 )
    CITATIONS (43)