ZFIN ID: ZDB-GENE-050420-109
Gene Name: signal-induced proliferation-associated 1 like 3
Gene Symbol: sipa1l3    Nomenclature History

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Previous Name: si:dkey-149j18.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have GTPase activator activity. Involved in lens development in camera-type eye. Is expressed in lens and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3).
Genome Resources: Alliance (1),  Gene:561005 (1),  Ensembl(GRCz11):ENSDARG00000061699 (2)
GENE EXPRESSION
All Expression Data: Fig. S3 from Greenlees et al., 2015
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: Expression Atlas (1)
PHENOTYPE
Data: Fig. 4 from Greenlees et al., 2015
Observed in:
DISEASE ASSOCIATED WITH sipa1l3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 45 Alliance ?Cataract 45 616851
DISEASE ASSOCIATED WITH sipa1l3 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
cataract WT + MO2-sipa1l3 standard conditions Greenlees et al., 2015
WT + MO1-sipa1l3 standard conditions Greenlees et al., 2015
GENE ONTOLOGY
Ontology GO Term
Biological Process lens development in camera-type eye (more)
Molecular Function GTPase activator activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sipa1l3-201 (1)    Ensembl 5035
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-sipa1l3 polyclonal Rabbit IHC Abcam plc
1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM sipa1l3 No data available
MARKER RELATIONSHIPS
sipa1l3 Contained in: [BAC] DKEY-52H13 (1) (order this), DKEY-149J18 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005173672 (1) 5817 nt
Genomic GenBank:BX571841 (1) 105977 nt
Select Tool
Polypeptide UniProtKB:A0A2R8RNK4 (1) 1718 aa
Sequence Information (all 15)
ORTHOLOGY for sipa1l3 ( Chr: 18 )
CITATIONS (14)