Gene
sipa1l3
- ID
- ZDB-GENE-050420-109
- Name
- signal-induced proliferation-associated 1 like 3
- Symbol
- sipa1l3 Nomenclature History
- Previous Names
-
- si:dkey-149j18.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in lens and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Greenlees et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Greenlees et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 45 | Alliance | ?Cataract 45 | 616851 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | WT + MO2-sipa1l3 | standard conditions | Greenlees et al., 2015 |
| cataract | WT + MO1-sipa1l3 | standard conditions | Greenlees et al., 2015 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000331 | Rap/Ran-GAP domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR021818 | Signal-induced proliferation-associated 1-like protein, C-terminal |
| Family | IPR031204 | Signal-induced proliferation-associated 1-like protein 3 |
| Homologous_superfamily | IPR035974 | Rap/Ran-GAP superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Length | PDZ domain | PDZ superfamily | Rap/Ran-GAP domain | Rap/Ran-GAP superfamily | Signal-induced proliferation-associated 1-like protein 3 | Signal-induced proliferation-associated 1-like protein, C-terminal |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8RNK4
|
1718 | ||||||
|
UniProtKB:F1QTH7
|
1678 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
sipa1l3-201
(1)
|
5035 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-sipa1l3 | polyclonal | Rabbit |
|
Abcam plc
|
1 |
Plasmids
No data available