Gene

sipa1l3

ID

ZDB-GENE-050420-109

Name

signal-induced proliferation-associated 1 like 3

Symbol

sipa1l3 Nomenclature History

Previous Names

si:dkey-149j18.1 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have GTPase activator activity. Involved in lens development in camera-type eye. Is expressed in lens and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3).

Genome Resources

Note

None

Expression

All Expression Data

from Greenlees et al., 2015

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: Fig. 4 from Greenlees et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sipa1l3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 45	Alliance	?Cataract 45	616851

Associated With sipa1l3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	WT + MO2-sipa1l3	standard conditions	Greenlees et al., 2015
cataract	WT + MO1-sipa1l3	standard conditions	Greenlees et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000331	Rap GTPase activating protein domain
Domain	IPR001478	PDZ domain
Domain	IPR021818	Signal-induced proliferation-associated 1-like protein, C-terminal
Family	IPR031204	Signal-induced proliferation-associated 1-like protein 3
Homologous_superfamily	IPR035974	Rap/Ran-GAP superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	PDZ domain	PDZ superfamily	Rap GTPase activating protein domain	Rap/Ran-GAP superfamily	Signal-induced proliferation-associated 1-like protein 3	Signal-induced proliferation-associated 1-like protein, C-terminal
UniProtKB:A0A2R8RNK4 InterPro	1718
UniProtKB:F1QTH7 InterPro	1678

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	sipa1l3-201 (1) Ensembl	5035 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-sipa1l3	polyclonal	sipa1l3		Rabbit	IHC	Abcam plc	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Ensembl Gene Tree

Citations