Gene

sipa1l3

ID
ZDB-GENE-050420-109
Name
signal-induced proliferation-associated 1 like 3
Symbol
sipa1l3 Nomenclature History
Previous Names
  • si:dkey-149j18.1 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have GTPase activator activity. Involved in lens development in camera-type eye. Is expressed in lens and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3).
Genome Resources
Note
None
Expression
All Expression Data
from Greenlees et al., 2015
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 4 from Greenlees et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sipa1l3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 45 Alliance ?Cataract 45 616851
Associated With sipa1l3 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000331 Rap GTPase activating protein domain
Domain IPR001478 PDZ domain
Domain IPR021818 Signal-induced proliferation-associated 1-like protein, C-terminal
Family IPR031204 Signal-induced proliferation-associated 1-like protein 3
Homologous_superfamily IPR035974 Rap/Ran-GAP superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length PDZ domain PDZ superfamily Rap GTPase activating protein domain Rap/Ran-GAP superfamily Signal-induced proliferation-associated 1-like protein 3 Signal-induced proliferation-associated 1-like protein, C-terminal
UniProtKB:A0A2R8RNK4 1718
UniProtKB:F1QTH7 1678
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sipa1l3 polyclonal Rabbit
  • IHC
Abcam plc
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations