ZFIN Gene: sipa1l3

ZFIN ID: ZDB-GENE-050420-109

ZFIN ID: ZDB-GENE-050420-109

Gene Name:

signal-induced proliferation-associated 1 like 3

Gene Symbol:

sipa1l3 Nomenclature History

Previous Name:

si:dkey-149j18.1 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 18 Mapping Details/Browsers

Description:

Predicted to have GTPase activator activity. Involved in lens development in camera-type eye. Is expressed in lens and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3).

Genome Resources:

Alliance (1), Gene:561005 (1), Ensembl(GRCz11):ENSDARG00000061699 (2)

GENE EXPRESSION
All Expression Data:	Fig. S3 from Greenlees et al., 2015
Wild-type Stages, Structures:	Segmentation:20-25 somites (19.0h-22.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	lens solid lens vesicle
High Throughput Expression:	Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa15094	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23346	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23347	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa36697	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43150	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43151	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa45646	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-sipa1l3	N/A	1
MO2-sipa1l3	N/A	1

PHENOTYPE

Data:	Fig. 4 from Greenlees et al., 2015
Observed in:	eye lens

DISEASE ASSOCIATED WITH sipa1l3 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 45	Alliance	?Cataract 45	616851

DISEASE ASSOCIATED WITH sipa1l3 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
cataract	WT + MO2-sipa1l3	standard conditions	Greenlees et al., 2015
	WT + MO1-sipa1l3	standard conditions	Greenlees et al., 2015

GENE ONTOLOGY

Ontology	GO Term
Biological Process	lens development in camera-type eye (more)
Molecular Function	GTPase activator activity (more)

GO Terms (all 3)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	sipa1l3-201 (1)	5035	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-sipa1l3	polyclonal		Rabbit	IHC	Abcam plc	1

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM sipa1l3 No data available

MARKER RELATIONSHIPS

sipa1l3 Contained in:

[BAC] DKEY-52H13 (1) (order this), DKEY-149J18 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005173672 (1)	5817 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571841 (1)	105977 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A2R8RNK4 (1)	1718 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 15)

ORTHOLOGY for sipa1l3 ( Chr: 18 )

CITATIONS (14)

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