ZFIN ID: ZDB-GENE-050419-182
Gene Name: MALT paracaspase 3
Gene Symbol: malt3    Nomenclature History

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Previous Name: si:dkey-77f17.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in lymphoma; non-Hodgkin lymphoma; and primary immunodeficiency disease. Orthologous to human MALT1 (MALT1 paracaspase).
Genome Resources: Alliance (1),  Gene:571242 (1),  Ensembl(GRCz11):ENSDARG00000068152 (2)
Note: Hulpiau, et al. (2016) demonstrate that this gene is orthologous to Malt3/Pcasp3 in chicken, turtle and frog, and they suggest that mammals lost MALT3.
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6521 Point Mutation Unknown Premature Stop ENU
sa10751 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36660 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36661 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH malt3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH malt3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Molecular Function cysteine-type endopeptidase activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001309 Peptidase C14, p20 domain
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR029030 Caspase-like domain superfamily
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Domain IPR041077 MALT1 immunoglobulin-like domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA malt3-201 (1)    Ensembl 2006
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM malt3 No data available
    MARKER RELATIONSHIPS
    malt3 Contained in: [BAC] DKEY-77F17 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021467817 (1)
    Genomic GenBank:AL935332 (1) 139084 bp
    Select Tool
    Polypeptide UniProtKB:Q1MT63 (1) 627 aa
    Sequence Information (all 12)
    ORTHOLOGY for malt3 ( Chr: 18 )
    CITATIONS (13)