Gene

malt3

ID
ZDB-GENE-050419-182
Name
MALT paracaspase 3
Symbol
malt3 Nomenclature History
Previous Names
  • si:dkey-77f17.1
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in lymphoma; non-Hodgkin lymphoma; and primary immunodeficiency disease. Orthologous to human MALT1 (MALT1 paracaspase).
Genome Resources
Note
Hulpiau, et al. (2016) demonstrate that this gene is orthologous to Malt3/Pcasp3 in chicken, turtle and frog, and they suggest that mammals lost MALT3.
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With malt3 Human Ortholog
No data available
Associated With malt3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR011600 Peptidase C14, caspase domain
Domain IPR041077 MALT1 immunoglobulin-like domain
Family IPR052039 Caspase-related proteases and regulators
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Homologous_superfamily IPR033540 MALT1, immunoglobulin-like domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Caspase-like domain superfamily Caspase-related proteases and regulators Immunoglobulin domain subtype Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype 2 MALT1 immunoglobulin-like domain MALT1, immunoglobulin-like domain superfamily Peptidase C14, caspase domain Peptidase C14, p20 domain
UniProtKB:A0A8N7T706 667
UniProtKB:A0A8M9PPL5 667
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA malt3-201 (1) Ensembl 2,006 nt
mRNA malt3-202 (1) Ensembl 2,175 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations