ZFIN ID: ZDB-GENE-050419-153
Gene Name: forkhead box F1
Gene Symbol: foxf1    Nomenclature History

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Previous Names: si:dkey-199i24.2 (1), zgc:158301 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in sprouting angiogenesis. Predicted to localize to nucleus. Is expressed in gut; head; swim bladder; and swim bladder bud. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to human FOXF1 (forkhead box F1).
Genome Resources: Alliance (1),  Gene:566407 (1),  Ensembl(GRCz11):ENSDARG00000015399 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el658 Small Deletion Unknown Unknown CRISPR
el660 Small Deletion Unknown Unknown CRISPR
stl88 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-foxf1 1
    MO1-foxf1 N/A 1
    DISEASE ASSOCIATED WITH foxf1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    persistent fetal circulation syndrome Alliance Alveolar capillary dysplasia with misalignment of pulmonary veins 265380
    DISEASE ASSOCIATED WITH foxf1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sprouting angiogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxf1-201 (1)    Ensembl 1383
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxf1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:foxf1,cryaa:Cerulean) cryaaUAS Ceruleanfoxf1 Danio rerio 1 1
    MARKER RELATIONSHIPS
    foxf1 Contained in: [BAC] DKEY-199I24 (1) (order this)
    foxf1 Encodes: [cDNA] MGC:158301 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080186 (1) 2153 nt
    Genomic GenBank:BX571798 (1) 108129 nt
    Select Tool
    Polypeptide UniProtKB:A1L1S5 (1) 380 aa
    Sequence Information (all 11)
    ORTHOLOGY for foxf1 ( Chr: 18 )
    CITATIONS (33)