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ZIRC
ZFIN ID: ZDB-GENE-050417-440
Gene Name: cholinergic receptor, nicotinic, alpha 5
Gene Symbol: chrna5    Nomenclature History

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Previous Name: zgc:110642

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to contribute to acetylcholine binding activity; acetylcholine receptor activity; and extracellular ligand-gated ion channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; regulation of membrane potential; and response to nicotine. Predicted to localize to the acetylcholine-gated channel complex; neuron projection; and synapse. Human ortholog(s) of this gene implicated in lung cancer. Is expressed in interpeduncular nucleus tegmentum and liver. Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit).
Genome Resources: Alliance (1),  Gene:550584 (1),  Ensembl(GRCz11):ENSDARG00000003420 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020436Tg Transgenic Insertion Unknown Unknown DNA
la027957Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa367 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23361 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45648 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chrna5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Lung cancer susceptibility 2} 612052
    {Nicotine dependence, susceptibility to} 612052
    DISEASE ASSOCIATED WITH chrna5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transmembrane transport (more)
    Cellular Component cell junction (more)
    Molecular Function acetylcholine-gated cation-selective channel activity (more)
    GO Terms (all 24)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chrna5-201 (1)    Ensembl 1752
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrna5 No data available
    MARKER RELATIONSHIPS
    chrna5 Contained in: [BAC] CH73-235D11 (1) (order this)
    chrna5 Encodes: [cDNA] MGC:110642 (1) (order this), MGC:191387 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001017885 (1) 1740 bp
    Genomic GenBank:CT027604 (1) 64306 bp
    Select Tool
    Polypeptide UniProtKB:Q567Y7 (1) 466 aa
    Sequence Clusters UniGene:87327 (1)
    Sequence Information (all 16)
    ORTHOLOGY for chrna5 ( Chr: 18 )
    CITATIONS (33)